Aerosol transmission is an important mode of influenza A virus spread

被引：252

作者：

Cowling, Benjamin J. ^{[1
]}

Ip, Dennis K. M. ^{[1
]}

Fang, Vicky J. ^{[1
]}

Suntarattiwong, Piyarat ^{[2
]}

Olsen, Sonja J. ^{[3
,4
]}

Levy, Jens ^{[3
]}

Uyeki, Timothy M. ^{[4
]}

Leung, Gabriel M. ^{[1
]}

Peiris, J. S. Malik ^{[1
,5
]}

Chotpitayasunondh, Tawee ^{[2
]}

Nishiura, Hiroshi ^{[1
,6
]}

Simmerman, James Mark ^{[7
]}

机构：

[1] Univ Hong Kong, Li Ka Shing Fac Med, Sch Publ Hlth, Hong Kong, Hong Kong, Peoples R China

[2] Queen Sirikit Natl Inst Child Hlth, Bangkok, Thailand

[3] Thailand MOPH US CDC Collaborat, Influenza Program, Nonthaburi, Thailand

[4] US Ctr Dis Control & Prevent, Influenza Div, Atlanta, GA 30333 USA

[5] Univ Hong Kong, Li Ka Shing Fac Med, Influenza Res Ctr, Hong Kong, Hong Kong, Peoples R China

[6] Japan Sci & Technol Agcy, PRESTO, Kawaguchi, Saitama 3320012, Japan

[7] Sanofi Pasteur, Epidemiol & Med Affairs, Bangkok, Thailand

来源：

NATURE COMMUNICATIONS | 2013年 / 4卷

关键词：

AIRBORNE TRANSMISSION; SURVIVAL; INFECTION; COMMUNITY; HYGIENE;

D O I：

10.1038/ncomms2922

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Influenza A viruses are believed to spread between humans through contact, large respiratory droplets and small particle droplet nuclei (aerosols), but the relative importance of each of these modes of transmission is unclear. Volunteer studies suggest that infections via aerosol transmission may have a higher risk of febrile illness. Here we apply a mathematical model to data from randomized controlled trials of hand hygiene and surgical face masks in Hong Kong and Bangkok households. In these particular environments, inferences on the relative importance of modes of transmission are facilitated by information on the timing of secondary infections and apparent differences in clinical presentation of secondary infections resulting from aerosol transmission. We find that aerosol transmission accounts for approximately half of all transmission events. This implies that measures to reduce transmission by contact or large droplets may not be sufficient to control influenza A virus transmission in households.

引用

页数：6

共 31 条

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