The biliary HCO3- umbrella: experimental evidence revisited

被引：42

作者：

Beuers, Ulrich ^{[1
]}

Maroni, Luca ^{[1
]}

Elferink, Ronald O. ^{[1
]}

机构：

[1] Univ Amsterdam, Dept Gastroenterol & Hepatol, Tytgat Inst Liver & Intestinal Res, Acad Med Ctr, NL-1100 DE Amsterdam, Netherlands

来源：

CURRENT OPINION IN GASTROENTEROLOGY | 2012年 / 28卷 / 03期

关键词：

bicarbonate umbrella; cystic fibrosis; nonanastomotic strictures; primary biliary cirrhosis; primary sclerosing cholangitis; NORURSODEOXYCHOLIC ACID; URSODEOXYCHOLIC ACID; ANTIMITOCHONDRIAL ANTIBODIES; BICARBONATE SECRETION; CHOLANGIOCYTES; MECHANISMS; RELEASE;

D O I：

10.1097/MOG.0b013e328352aab2

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Purpose of review To critically review most recent experimental evidence for the protective action of biliary HCO3- secretion against bile acid-induced bile duct damage and development of fibrosing cholangiopathy in humans and experimental animals. Recent findings Studies in human cholangiocytes in vitro indicate that a biliary HCO3- umbrella protects against bile acid-induced cholangiocyte damage and apoptosis in humans. The Cl-/HCO3- exchanger, AE2, and an intact biliary glycocalyx appear crucial for its stability. Related studies with experimental animal models in vivo have to be interpreted with caution as humans and mice differ not only with regard to bile salt pool, but also their expression patterns of transport proteins and signalling molecules. Summary Adequate biliary HCO3- secretion may protect against bile salt-induced cholangiopathies. Future therapeutic strategies in biliary diseases will aim at stabilizing the biliary HCO3- umbrella.

引用

收藏

页码：253 / 257

页数：5

相关论文

共 33 条

[1]

Morphological, molecular, and functional heterogeneity of cholangiocytes from normal rat liver [J].

Alpini, G ;

Roberts, S ;

Kuntz, SM ;

Ueno, Y ;

Gubba, S ;

Podila, PV ;

LeSage, G ;

LaRusso, NF .

GASTROENTEROLOGY, 1996, 110 (05) :1636-1643

[2]

Dual Farnesoid X Receptor/TGR5 Agonist INT-767 Reduces Liver Injury in the Mdr2-/- (Abcb4-/-) Mouse Cholangiopathy Model by Promoting Biliary HCO3- Output [J].

Baghdasaryan, Anna ;

Claudel, Thierry ;

Gumhold, Judith ;

Silbert, Dagmar ;

Adorini, Luciano ;

Roda, Aldo ;

Vecchiotti, Stefania ;

Gonzalez, Frank J. ;

Schoonjans, Kristina ;

Strazzabosco, Mario ;

Fickert, Peter ;

Trauner, Michael .

HEPATOLOGY, 2011, 54 (04) :1303-1312

[3]

Drug insight: mechanisms and sites of action of ursodeoxycholic acid in cholestasis [J].

Beuers, Ulrich .

NATURE CLINICAL PRACTICE GASTROENTEROLOGY & HEPATOLOGY, 2006, 3 (06) :318-328

[4]

The Binary HCO3- Umbrella: A Unifying Hypothesis on Pathogenetic and Therapeutic Aspects of Fibrosing Cholangiopathies [J].

Beuers, Ulrich ;

Hohenester, Simon ;

Wenniger, Lucas J. Maillette de Buy ;

Kremer, Andreas E. ;

Jansen, Peter L. M. ;

Elferink, Ronald P. J. Oude .

HEPATOLOGY, 2010, 52 (04) :1489-1496

[5]

EASL Clinical Practice Guidelines: Management of cholestatic liver diseases [J].

Beuers, Ulrich ;

Boberg, Kirsten M. ;

Chapman, Roger W. ;

Chazouilleres, Olivier ;

Invernizzi, Pietro ;

Jones, David E. J. ;

Lammert, Frank ;

Pares, Albert ;

Trauner, Michael .

JOURNAL OF HEPATOLOGY, 2009, 51 (02) :237-267

[6]

Boyer J. L., 1986, PHYSL MEMBRANE DISOR, P609, DOI DOI 10.1007/978-1-4613-2097-5_35

[7]

Hu Antigen R and Tristetraprolin: Counter-Regulators of Rat Apical Sodium-Dependent Bile Acid Transporter by Way of Effects on Messenger RNA Stability [J].

Chen, Frank ;

Shyu, Ann-Bin ;

Shneider, Benjamin L. .

HEPATOLOGY, 2011, 54 (04) :1371-1378

[8]

LOCALIZATION OF THE CYSTIC-FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR IN HUMAN BILE-DUCT EPITHELIAL-CELLS [J].

COHN, JA ;

STRONG, TV ;

PICCIOTTO, MR ;

NAIRN, AC ;

COLLINS, FS ;

FITZ, JG .

GASTROENTEROLOGY, 1993, 105 (06) :1857-1864

[9]

Conjugation Is Essential for the Anticholestatic Effect of NorUrsodeoxycholic Acid in Taurolithocholic Acid-Induced Cholestasis in Rat Liver [J].

Denk, Gerald U. ;

Maitz, Silvia ;

Wimmer, Ralf ;

Rust, Christian ;

Invernizzi, Pietro ;

Ferdinandusse, Sacha ;

Kulik, Wim ;

Fuchsbichler, Andrea ;

Fickert, Peter ;

Trauner, Michael ;

Hofmann, Alan F. ;

Beuers, Ulrich .

HEPATOLOGY, 2010, 52 (05) :1758-1768

[10]

Identification and Functional Characterization of TMEM16A, a Ca2+-activated Cl- Channel Activated by Extracellular Nucleotides, in Biliary Epithelium [J].

Dutta, Amal K. ;

Khimji, Al-karim ;

Kresge, Charles ;

Bugde, Abhijit ;

Dougherty, Michael ;

Esser, Victoria ;

Ueno, Yoshiyuki ;

Glaser, Shannon S. ;

Alpini, Gianfranco ;

Rockey, Don C. ;

Feranchak, Andrew P. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (01) :766-776

← 1 2 3 4 →