The rationale for targeting the LOX family in cancer

被引：466

作者：

Barker, Holly E. ^{[1
]}

Cox, Thomas R. ^{[1
,2
,3
]}

Erler, Janine T. ^{[1
,2
,3
]}

机构：

[1] Inst Canc Res, Hypoxia & Metastasis Team, London SW3 6JB, England

[2] Inst Canc Res, CRUK Tumour Cell Signalling Unit, Div Canc Biol, London SW3 6JB, England

[3] Univ Copenhagen, BRIC, DK-2200 Copenhagen, Denmark

来源：

NATURE REVIEWS CANCER | 2012年 / 12卷 / 08期

关键词：

LYSYL OXIDASE-LIKE; GROWTH-FACTOR-BETA; SINGLE-NUCLEOTIDE POLYMORPHISMS; TUMOR-SUPPRESSOR ACTIVITY; GENE-EXPRESSION PROFILES; SQUAMOUS-CELL CARCINOMAS; COMMON SEQUENCE VARIANTS; FIBROTIC FOCUS; AMINE OXIDASE; EXTRACELLULAR-MATRIX;

D O I：

10.1038/nrc3319

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The therapeutic targeting of extracellular proteins is becoming hugely attractive in light of evidence implicating the tumour microenvironment as pivotal in all aspects of tumour initiation and progression. Members of the lysyl oxidase (LOX) family of proteins are secreted by tumours and are the subject of much effort to understand their roles in cancer. In this Review we discuss the roles of members of this family in the remodelling of the tumour microenvironment and their paradoxical roles in tumorigenesis and metastasis. We also discuss how targeting this family of proteins might lead to a new avenue of cancer therapeutics.

引用

页码：540 / 552

页数：13

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