Developmental regulation of presenilin mRNA expression parallels notch expression

被引:63
作者
Berezovska, O
Xia, MQ
Page, K
Wasco, W
Tanzi, RE
Hyman, BT
机构
[1] MASSACHUSETTS GEN HOSP EAST, ALZHEIMER RES UNIT, CHARLESTOWN, MA 02129 USA
[2] HARVARD UNIV, SCH MED, MASSACHUSETTS GEN HOSP, BOSTON, MA 02114 USA
关键词
Alzheimer disease; development; notch; presenilins;
D O I
10.1097/00005072-199701000-00004
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Mutations in the presenilin (PS) 1 and 2 genes are associated with autosomal dominant Alzheimer disease. PS1 shares striking homology with sel-12, a C. elegans gene implicated in the function of lin-12/Notch, a protein important in neurogenesis. We studied mRNA expression using RT-PCR and in situ hybridization techniques during neural development in mouse and rat. Strong expression of PSs and Notch1 was observed in embryos, especially in the ventricular zone, which decreased gradually as embryos developed. Very low levels of PSs and Notch were present in adulthood, their signals present primarily in the hippocampus and cerebellum. These observations show that, like Notch, PS1 and PS2 are strongly developmentally regulated, and support the plausibility of an interaction between PSs and Notch.
引用
收藏
页码:40 / 44
页数:5
相关论文
共 17 条
[1]   INVOLVEMENT OF NOTCH-1 IN MAMMALIAN RETINAL NEUROGENESIS - ASSOCIATION OF NOTCH-1 ACTIVITY WITH BOTH IMMATURE AND TERMINALLY DIFFERENTIATED CELLS [J].
AHMAD, I ;
ZAGOURAS, P ;
ARTAVANISTSAKONAS, S .
MECHANISMS OF DEVELOPMENT, 1995, 53 (01) :73-85
[2]   NOTCH SIGNALING [J].
ARTAVANISTSAKONAS, S ;
MATSUNO, K ;
FORTINI, ME .
SCIENCE, 1995, 268 (5208) :225-232
[3]   THE ROLE OF NOTCH IN LATERAL INHIBITION AND CELL FATE SPECIFICATION [J].
CHITNIS, AB .
MOLECULAR AND CELLULAR NEUROSCIENCE, 1995, 6 (04) :311-321
[4]   THE STRUCTURE OF THE PRESENILIN-1 (S182) GENE AND IDENTIFICATION OF 6 NOVEL MUTATIONS IN EARLY-ONSET AD FAMILIES [J].
CLARK, RF ;
HUTTON, M ;
FULDNER, RA ;
FROELICH, S ;
KARRAN, E ;
TALBOT, C ;
CROOK, R ;
LENDON, C ;
PRIHAR, G ;
HE, C ;
KORENBLAT, K ;
MARTINEZ, A ;
WRAGG, M ;
BUSFIELD, F ;
BEHRENS, MI ;
MYERS, A ;
NORTON, J ;
MORRIS, J ;
MEHTA, N ;
PEARSON, C ;
LINCOLN, S ;
BAKER, M ;
DUFF, K ;
ZEHR, C ;
PEREZTUR, J ;
HOULDEN, H ;
RUIZ, A ;
OSSA, J ;
LOPERA, F ;
ARCOS, M ;
MADRIGAL, L ;
COLLINGE, J ;
HUMPHREYS, C ;
ASHWORTH, A ;
SARNER, S ;
FOX, N ;
HARVEY, R ;
KENNEDY, A ;
ROQUES, P ;
CLINE, RT ;
PHILLIPS, CA ;
VENTER, JC ;
FORSELL, L ;
AXELMAN, K ;
LILIUS, L ;
JOHNSTON, J ;
COWBURN, R ;
VIITANEN, M ;
WINBLAD, B ;
KOSIK, K .
NATURE GENETICS, 1995, 11 (02) :219-222
[5]   DIFFERENTIAL EXPRESSION OF NOTCH1 AND NOTCH2 IN DEVELOPING AND ADULT-MOUSE BRAIN [J].
HIGUCHI, M ;
KIYAMA, H ;
HAYAKAWA, T ;
HAMADA, Y ;
TSUJIMOTO, Y .
MOLECULAR BRAIN RESEARCH, 1995, 29 (02) :263-272
[6]   SIGNALING DOWNSTREAM OF ACTIVATED MAMMALIAN NOTCH [J].
JARRIAULT, S ;
BROU, C ;
LOGEAT, F ;
SCHROETER, EH ;
KOPAN, R ;
ISRAEL, A .
NATURE, 1995, 377 (6547) :355-358
[7]   Alzheimer-associated presenilins 1 and 2: Neuronal expression in brain and localization to intracellular membranes in mammalian cells [J].
Kovacs, DM ;
Fausett, HJ ;
Page, KJ ;
Kim, TW ;
Moir, RD ;
Merriam, DE ;
Hollister, RD ;
Hallmark, OG ;
Mancini, R ;
Felsenstein, KM ;
Hyman, BT ;
Tanzi, RE ;
Wasco, W .
NATURE MEDICINE, 1996, 2 (02) :224-229
[8]   THE NOVEL NOTCH HOMOLOG MOUSE NOTCH-3 LACKS SPECIFIC EPIDERMAL GROWTH FACTOR-REPEATS AND IS EXPRESSED IN PROLIFERATING NEUROEPITHELIUM [J].
LARDELLI, M ;
DAHLSTRAND, J ;
LENDAHL, U .
MECHANISMS OF DEVELOPMENT, 1994, 46 (02) :123-136
[9]   FACILITATION OF LIN-12-MEDIATED SIGNALING BY SEL-12, A CAENORHABDITIS-ELEGANS S182 ALZHEIMERS-DISEASE GENE [J].
LEVITAN, D ;
GREENWALD, I .
NATURE, 1995, 377 (6547) :351-354
[10]   CANDIDATE GENE FOR THE CHROMOSOME-1 FAMILIAL ALZHEIMERS-DISEASE LOCUS [J].
LEVYLAHAD, E ;
WASCO, W ;
POORKAJ, P ;
ROMANO, DM ;
OSHIMA, J ;
PETTINGELL, WH ;
YU, CE ;
JONDRO, PD ;
SCHMIDT, SD ;
WANG, K ;
CROWLEY, AC ;
FU, YH ;
GUENETTE, SY ;
GALAS, D ;
NEMENS, E ;
WIJSMAN, EM ;
BIRD, TD ;
SCHELLENBERG, GD ;
TANZI, RE .
SCIENCE, 1995, 269 (5226) :973-977