Four new C19 homolignans, schiarisanrins A, B, and D and cytotoxic schiarisanrin C, from Schizandra arisanensis

被引：98

作者：

Kuo, YH

Kuo, LMY

Chen, CF

机构：

[1] National Res. Inst. Chin. Medicine, Shih-Pai, Taipei 112, Li-Nong St.

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1997年 / 62卷 / 10期

关键词：

D O I：

10.1021/jo9622542

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Four new C-19 homolignans with a 5,4'-butano-2,4-cyclohexadienone-6-spiro-3'-(2',3'-dihydrobenzo- [b]furan) skeleton, schiarisanrin A, schiarisanrin B, schiarisanrin D, and cytotoxic schiarisanrin C, were isolated from Schizandra arisanensis. Their structure and stereochemistry have been established by spectral and single-crystal X-ray analysis. Schiarisanrin C has cytotoxic activity with ED50 values of 0.36, 7.1, 4.9, and 5.7 mu g/mL, respectively, against KB epidermoid carcinoma of nasopharynx, COLO-205 colon carcinoma, HEPA hepatoma, and HELA cervix tumor cells.

引用

页码：3242 / 3245

页数：4

共 17 条

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[2]

CHEN CF, 1990, CHIN MED J TAIPEI, V46, P7

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