Synthesis and antibacterial activity of new tropone-substituted phenyloxazolidinone antibacterial agents .1. Identification of leads and importance of the tropone substitution pattern.

被引：13

作者：

Barbachyn, MR

Toops, DS

Ulanowicz, DA

Grega, KC

Brickner, SJ

Ford, CW

Zurenko, GE

Hamel, JC

Schaadt, RD

Stapert, D

Yagi, BH

Buysse, JM

Demyan, WF

Kilburn, JO

Glickman, SE

机构：

[1] PHARM & UPJOHN INC,CANC & INFECT DIS RES,KALAMAZOO,MI 49001

[2] PHARM & UPJOHN INC,MOLEC BIOL RES,KALAMAZOO,MI 49001

[3] CTR DIS CONTROL,ATLANTA,GA 30333

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 09期

关键词：

D O I：

10.1016/0960-894X(96)00154-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Incorporation of a substituted tropone moiety into the para position of suitably functionalized 3-phenyl-2-oxazolidinones affords novel and potent antibacterial agents. The effect of the tropone regioisomer and its attendant substituents on antibacterial activity is discussed. Analogues such as 11c and 13b display in vitro and in vivo activity approaching that of the current clinical benchmark, vancomycin. (C) 1996 Elsevier Science Ltd.

引用

页码：1003 / 1008

页数：6

共 19 条

[1]

*AM SOC MICR, 1995, 35 INT C ANT AG CHEM

[2] OXIDATION OF VICINAL DIOLS TO ALPHA-DICARBONYL COMPOUNDS BY TRIFLUOROACETIC-ANHYDRIDE ACTIVATED DIMETHYLSULFOXIDE [J].