Antibody response against gastrointestinal antigens in demyelinating diseases of the central nervous system

被引：63

作者：

Banati, M. ^{[1
]}

Csecsei, P. ^{[1
]}

Koszegi, E. ^{[1
]}

Nielsen, H. H. ^{[2
]}

Suto, G. ^{[3
]}

Bors, L. ^{[1
]}

Trauninger, A. ^{[1
]}

Csepany, T. ^{[4
]}

Rozsa, C. ^{[5
]}

Jakab, G. ^{[6
]}

Molnar, T. ^{[7
]}

Berthele, A. ^{[8
]}

Kalluri, S. R. ^{[8
]}

Berki, T. ^{[9
]}

Illes, Z. ^{[1
,2
]}

机构：

[1] Univ Pecs, Dept Neurol, H-7623 Pecs, Hungary

[2] Univ Southern Denmark, Odense Univ Hosp, Dept Neurol, Odense, Denmark

[3] Univ Pecs, Dept Rheumatol & Clin Immunol, H-7623 Pecs, Hungary

[4] Univ Debrecen, Dept Neurol, H-4012 Debrecen, Hungary

[5] Jahn Ferenc Teaching Hosp, Dept Neurol, Budapest, Hungary

[6] Uzsoki Teaching Hosp, Dept Neurol, Budapest, Hungary

[7] Univ Pecs, Dept Anesthesiol & Intens Care, H-7623 Pecs, Hungary

[8] Tech Univ Munich, Klinikum Rechts Isar, Dept Neurol, D-80290 Munich, Germany

[9] Univ Pecs, Dept Immunol & Biotechnol, H-7623 Pecs, Hungary

来源：

EUROPEAN JOURNAL OF NEUROLOGY | 2013年 / 20卷 / 11期

关键词：

anti-Saccharomyces cerevisiae; aquaporin; 4; gliadin; intrinsic factor; multiple sclerosis; myelitis; neuromyelitis optica; optic neuritis; parietal cell; transglutaminase; INFLAMMATORY-BOWEL-DISEASE; TISSUE TRANSGLUTAMINASE ANTIBODIES; WHITE-MATTER LESIONS; NEUROMYELITIS-OPTICA; CELIAC-DISEASE; MULTIPLE-SCLEROSIS; DIAGNOSTIC-CRITERIA; GLUTEN SENSITIVITY; AQUAPORIN-4; GUIDELINES;

D O I：

10.1111/ene.12072

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

BackgroundAntibodies against gastrointestinal antigens may indicate altered microbiota and immune responses in the gut. Recent experimental data suggest a connection between gastrointestinal immune responses and CNS autoimmunity. MethodsAntibodies against gliadin, tissue transglutaminase (tTG), intrinsic factor (IF), parietal cells (PC) and Saccharomyces cerevisiae (ASCA) were screened in the sera of 45 patients with AQP4-seropositive neuromyelitis optica (NMO) and NMO spectrum diseases (NMO/NMO-SD), 17 patients with AQP4-seronegative NMO, 85 patients with clinically definite multiple sclerosis (MS), and 48 healthy controls (HC). ResultsThirty-seven percentages of patients with AQP4-seropositive NMO/NMO-SD and 28% of patients with MS had at least one particular antibody in contrast to 8% of HC (P<0.01, respectively). Antibodies were most common (46%) in AQP4-seropositive myelitis (P=0.01 versus HS, P=0.05 versus MS). Anti-gliadin and ASCA were more frequent in the AQP4-seropositive NMO-spectrum compared to controls (P=0.01 and P<0.05, respectively). ConclusionAntibody responses against gastrointestinal antigens are common in MS and AQP4-seropositive NMO/NMO-SD, especially in longitudinally extensive myelitis.

引用

页码：1492 / 1495

页数：4

共 25 条

[1]

Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination [J].