The non-invasive acetylene rebreathing method for estimation of cardiac output: Influence of breath-by-breath variation

被引:5
作者
Hansen, S [1 ]
Wendelboe, O [1 ]
Christensen, P [1 ]
机构
[1] ODENSE UNIV HOSP,DEPT ANAESTHESIOL,DK-5000 ODENSE C,DENMARK
来源
CLINICAL PHYSIOLOGY | 1997年 / 17卷 / 02期
关键词
computer simulation; functional residual capacity; lung model; lung tissue volume; mass spectrometry; pulmonary capillary blood flow; diffusing capacity;
D O I
10.1046/j.1365-2281.1997.02525.x
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
The inert gas rebreathing method enables non-invasive estimation of pulmonary capillary blood flow, lung tissue volume, transfer factor and functional residual capacity. In the present study, we have examined the influence of breathing pattern during the rebreathing manoeuvre on the precision of the rebreathing method, both theoretically and experimentally. We examined whether the precision of the method could be improved by the guidance and training of the subjects doing the rebreathing manoeuvre. The results of the theoretical study showed that the precision and accuracy of the rebreathing method are practically insensitive to random variation in the breathing pattern. Simulated breath-by-breath variations up to +/-50% of the average 3.01 V-T resulted in coefficients of variation of about 3% for Q(C) and about 5% for V-TC. Simulated breath-by-breath variations indicate that with mean tidal volume or rebreathing bag volume lower than 1.01 the precision will worsen, and with tidal volume lower than 1.5 1 the accuracy will worsen. The experimental results showed no significant improvement in the precision of the rebreathing method by visual guiding and training of the subjects to optimize the breathing pattern during the rebreathing manoeuvre.
引用
收藏
页码:193 / 202
页数:10
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