BDNF and memory processing

被引：272

作者：

Bekinschtein, Pedro ^{[1
]}

Cammarota, Martin ^{[2
]}

Medina, Jorge H. ^{[1
,3
]}

机构：

[1] UBA, Fac Med, Inst Biol Celular & Neurociencias, RA-1121 Buenos Aires, DF, Argentina

[2] Univ Fed Rio Grande do Norte, Inst Cerebro, BR-59056450 Natal, RN, Brazil

[3] UBA, Fac Med, Dept Fisiol, RA-1121 Buenos Aires, DF, Argentina

来源：

NEUROPHARMACOLOGY | 2014年 / 76卷

关键词：

Long-term memory; Memory persistence; Hippocampus; Prefrontal cortex; Neurotrophins; LONG-TERM-MEMORY; HIPPOCAMPAL SYNAPTIC PLASTICITY; MEDIAL PREFRONTAL CORTEX; DENDRITIC SPINE DENSITY; CA1 PYRAMIDAL NEURONS; C-FOS EXPRESSION; NEUROTROPHIC-FACTOR; PROTEIN-SYNTHESIS; VAL66MET POLYMORPHISM; SPATIAL MEMORY;

D O I：

10.1016/j.neuropharm.2013.04.024

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Brain-derived neurotrophic factor has emerged as one of the most important molecules involved in memory. Its wide role in different types of memories that depend on different structures as well as its involvement in distinct memory stages points at BDNF as one likely target to treat cognitive impairments and anxiety-related memory disorders. However, regulation of BDNF expression is very complex as well as its modes of action. Here we describe the latest research carried out on the function of BDNF in memory to illustrate such complexity. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：677 / 683

页数：7

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