Sex differences in the growth of white matter during adolescence

被引：143

作者：

Perrin, J. S. ^{[1
]}

Leonard, G. ^{[2
]}

Perron, M.

Pike, G. B. ^{[2
]}

Pitiot, A. ^{[1
]}

Richer, L. ^{[4
]}

Veillette, S.

Pausova, Z. ^{[1
,3
]}

PauS, T. ^{[1
,2
]}

机构：

[1] Univ Nottingham, Brain & Body Ctr, Nottingham NG7 2RD, England

[2] McGill Univ, Montreal Neurol Inst, Montreal, PQ, Canada

[3] Univ Montreal, Ctr Rech, Ctr Hosp, Montreal, PQ, Canada

[4] Univ Quebec, Dept Psychol, Chicoutimi, PQ, Canada

来源：

NEUROIMAGE | 2009年 / 45卷 / 04期

基金：

加拿大健康研究院;

关键词：

ADULT HUMAN BRAIN; CORPUS-CALLOSUM; MAGNETIZATION-TRANSFER; MORPHOMETRIC ANALYSIS; IN-VIVO; MRI; DIMORPHISM; CHILDHOOD; ARCHITECTURE; EXPRESSION;

D O I：

10.1016/j.neuroimage.2009.01.023

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The purpose of this study was to examine sex differences in the maturation of white matter during adolescence ( 12 to 18 years of age). We measured lobular volumes of white matter and white-matter "density" throughout the brain using T1-weighted images, and estimated the myelination index using magnetisation-transfer ratio (MTR). In male adolescents, we observed age-related increases in white-matter lobular volumes accompanied by decreases in the lobular values of white-matter MTR. White-matter density in the putative cortico-spinal tract (pCST) decreased with age. In female adolescents, on the other hand, we found only small age-related increase in white-matter volumes and no age-related changes in white-matter MTR, with the exception of the frontal lobe where MTR increased. White-matter density in the pCST also increased with age. These results suggest that sex-specific mechanisms may underlie the growth of white matter during adolescence. We speculate that these mechanisms involve primarily age-related increases in axonal calibre in males and increased myelination in females. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：1055 / 1066

页数：12

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