The neuroprotective effect of DL-tetrahydropalmatine in rat heatstroke

被引：15

作者：

Chang, CK

Chueh, FY

Hsieh, MT

Lin, MT ^{[1
]}

机构：

[1] Natl Yang Ming Univ, Inst Physiol, Taipei 112, Taiwan

[2] Natl Res Inst Chinese Med, Taipei, Taiwan

[3] China Med Coll, Inst Chinese Pharmaceut Sci, Taichung 40227, Taiwan

来源：

NEUROSCIENCE LETTERS | 1999年 / 267卷 / 02期

关键词：

heatstroke; tetrahydroxypalmatine; brain; monoamines; cerebral ischemia; neuronal injury;

D O I：

10.1016/S0304-3940(99)00322-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

After the onset of heatstroke, rats with saline injection displayed hyperthermia, decreased mean arterial pressure, decreased cerebral blood flow, increased brain monoamine release, and increased neuronal damage score compared with those of normothermia, control rats. The heatstroke-induced hyperthermia, arterial hypotension, cerebral ischemia, brain monoamine overload, and cerebral neuronal injury were attenuated by pretreatment with dl-tetrahydropalmatine. The data indicate that DL-tetrahydropalmatine pretreatment provides neuroprotective effect in heatstroke. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：109 / 112

页数：4

共 19 条

[1] Interleukin-1 receptor antagonist increases survival in rat heatstroke by reducing hypothalamic serotonin release [J].