The Effects of Vertical Sleeve Gastrectomy in Rodents Are Ghrelin Independent

被引：122

作者：

Chambers, Adam P. ^{[1
]}

Kirchner, Henriette ^{[1
]}

Wilson-Perez, Hilary E. ^{[1
]}

Willency, Jill A. ^{[2
]}

Hale, John E. ^{[3
]}

Gaylinn, Bruce D. ^{[4
,5
]}

Thorner, Michael O. ^{[4
,5
]}

Pfluger, Paul T. ^{[4
,5
]}

Gutierrez, Jesus A. ^{[2
]}

Tschoep, Matthias H. ^{[4
,5
]}

Sandoval, Darleen A. ^{[1
]}

Seeley, Randy J. ^{[1
]}

机构：

[1] Univ Cincinnati, Metab Dis Inst, Cincinnati, OH 45237 USA

[2] Eli Lilly & Co, Lilly Res Labs, Translat Sci & Technol, Indianapolis, IN 46285 USA

[3] Univ Virginia, Div Endocrinol & Metab, Charlottesville, VA USA

[4] Helmholtz Ctr Munich, Inst Diabet & Obes, Munich, Germany

[5] Tech Univ Munich, D-80290 Munich, Germany

来源：

GASTROENTEROLOGY | 2013年 / 144卷 / 01期

基金：

加拿大健康研究院;

关键词：

Weight-Loss Surgery; Obesity; Treatment; Bariatric; Surgery; WEIGHT;

D O I：

10.1053/j.gastro.2012.09.009

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Reductions in levels of the hunger-stimulating hormone ghrelin have been proposed to mediate part of the effects of vertical sleeve gastrectomy (VSG) and Roux-en-Y gastric bypass surgeries for obesity. We studied circulating levels of acyl and desacyl ghrelin in rats after these surgeries. We found that blood levels of ghrelin were reduced after VSG, but not after Roux-en-Y gastric bypass, based on enzyme-linked immunosorbent assay and mass-spectrometry analyses. We compared the effects of VSG in ghrelin-deficient mice and wild-type mice on food intake, body weight, dietary fat preference, and glucose tolerance. We found that VSG produced comparable outcomes in each strain. Reduced ghrelin signaling therefore does not appear to be required for these effects of VSG.

引用

页码：50 / U124

页数：8

共 10 条

[1] Weight and Type 2 Diabetes after Bariatric Surgery: Systematic Review and Meta-analysis [J].

Buchwald, Henry ;

Estok, Rhonda ;

Fahrbach, Kyle ;

Banel, Deirdre ;

Jensen, Michael D. ;

Pories, Walter J. ;

Bantle, John P. ;

Sledge, Isabella .

AMERICAN JOURNAL OF MEDICINE, 2009, 122 (03) :248-U81

[2] Weight-Independent Changes in Blood Glucose Homeostasis After Gastric Bypass or Vertical Sleeve Gastrectomy in Rats [J].

Chambers, Adam P. ;

Jessen, Lene ;

Ryan, Karen K. ;

Sisley, Stephanie ;

Wilson-Perez, Hilary E. ;

Stefater, Margaret A. ;

Gaitonde, Shrawan G. ;

Sorrell, Joyce E. ;

Toure, Mouhamadoul ;

Berger, Jose ;

D'Alessio, David A. ;

Woods, Stephen C. ;

Seeley, Randy J. ;

Sandoval, Darleen A. .

GASTROENTEROLOGY, 2011, 141 (03) :950-958

[3] Ghrelin octanoylation mediated by an orphan lipid transferase [J].

Gutierrez, Jesus A. ;

Solenberg, Patricia J. ;

Perkins, Douglas R. ;

Willency, Jill A. ;

Knierman, Michael D. ;

Jin, Zhaoyan ;

Witcher, Derrick R. ;

Luo, Shuang ;

Onyia, Jude E. ;

Hale, John E. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (17) :6320-6325

[4] Novel ghrelin assays provide evidence for independent regulation of ghrelin acylation and secretion in healthy young men [J].

Liu, Jianhua ;

Prudom, Catherine E. ;

Nass, Ralf ;

Pezzoli, Suzan S. ;

Oliveri, Mary C. ;

Johnson, Michael L. ;

Veldhuis, Paula ;

Gordon, David A. ;

Howard, Andrew D. ;

Witcher, Derrick R. ;

Geysen, H. Mario ;

Gaylinn, Bruce D. ;

Thorner, Michael O. .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2008, 93 (05) :1980-1987

[5] Pharmacologic Inhibition of Ghrelin Receptor Signaling Is Insulin Sparing and Promotes Insulin Sensitivity [J].

Longo, Kenneth A. ;

Govek, Elizabeth K. ;

Nolan, Anna ;

McDonagh, Thomas ;

Charoenthongtrakul, Soratree ;

Giuliana, Derek J. ;

Morgan, Kristen ;

Hixon, Jeffrey ;

Zhou, Chaoseng ;

Kelder, Bruce ;

Kopchick, John J. ;

Saunders, Jeffrey O. ;

Navia, Manuel A. ;

Curtis, Rory ;

DiStefano, Peter S. ;

Geddes, Brad J. .

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2011, 339 (01) :115-124

[6] Ghrelin modulates brain activity in areas that control appetitive behavior [J].

Malik, Saima ;

McGlone, Francis ;

Bedrossian, Diane ;

Dagher, Alain .

CELL METABOLISM, 2008, 7 (05) :400-409

[7] Simultaneous deletion of ghrelin and its receptor increases motor activity and energy expenditure [J].

Pfluger, Paul T. ;

Kirchner, Henriette ;

Guennel, Susanne ;

Schrott, Brigitte ;

Perez-Tilve, Diego ;

Fu, Sheng ;

Benoit, Stephen C. ;

Horvath, Tamas ;

Joost, Hans-Georg ;

Wortley, Katherine E. ;

Sleeman, Mark W. ;

Tschoep, Matthias H. .

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2008, 294 (03) :G610-G618

[8]

Wilson-Perez HE, 2012, INT J OBES LOND, V33, P595

[9] Absence of ghrelin protects against early-onset obesity [J].

Wortley, KE ;

del Rincon, JP ;

Murray, JD ;

Garcia, K ;

Lida, K ;

Thorner, MO ;

Sleeman, MW .

JOURNAL OF CLINICAL INVESTIGATION, 2005, 115 (12) :3573-3578

[10] Ghrelin enhances appetite and increases food intake in humans [J].

Wren, AM ;

Seal, LJ ;

Cohen, MA ;

Brynes, AE ;

Frost, GS ;

Murphy, KG ;

Dhillo, WS ;

Ghatei, MA ;

Bloom, SR .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2001, 86 (12) :5992-5995

← 1 →