Sensorimotor Plasticity after Music-Supported Therapy in Chronic Stroke Patients Revealed by Transcranial Magnetic Stimulation

被引：66

作者：

Amengual, Julia L. ^{[1
,2
,3
]}

Rojo, Nuria ^{[1
,3
]}

de Las Heras, Misericordia Veciana ^{[4
]}

Marco-Pallares, Josep ^{[1
,3
]}

Grau-Sanchez, Jennifer ^{[1
,3
]}

Schneider, Sabine ^{[5
]}

Vaquero, Lucia ^{[1
,3
]}

Juncadella, Montserrat ^{[4
]}

Montero, Jordi ^{[4
]}

Mohammadi, Bahram ^{[6
]}

Rubio, Francisco ^{[4
]}

Rueda, Nohora ^{[7
]}

Duarte, Esther ^{[7
]}

Grau, Carles ^{[2
]}

Altenmueller, Eckart ^{[5
]}

Muente, Thomas F. ^{[8
]}

Rodriguez-Fornells, Antoni ^{[1
,3
,9
]}

机构：

[1] Bellvitge Biomed Res Inst, Cognit & Brain Plast Grp, Barcelona, Spain

[2] Univ Barcelona, Dept Psychiat & Clin Psychobiol, Neurodynam Lab, Barcelona, Spain

[3] Univ Barcelona, Dept Basic Psychol, Barcelona, Spain

[4] Univ Barcelona, Hosp Univ Bellvitge, Neurol Sect, Bellvitge Biomed Res Inst, Barcelona, Spain

[5] Univ Mus & Drama Hannover, Inst Mus Physiol & Musicians Med, Hannover, Germany

[6] Int Neurosci Inst Hannover, Hannover, Germany

[7] Hosp Mar & Esperanca, Dept Phys Med & Rehabil, Barcelona, Spain

[8] Med Univ Lubeck, Dept Neurol, D-23538 Lubeck, Germany

[9] Catalan Inst Res & Adv Studies, Barcelona, Spain

来源：

PLOS ONE | 2013年 / 8卷 / 04期

关键词：

POSITRON-EMISSION-TOMOGRAPHY; HUMAN MOTOR CORTEX; LONG-TERM CHANGES; BRAIN PLASTICITY; SUBCORTICAL STROKE; FOLLOW-UP; REORGANIZATION; RECOVERY; EXCITABILITY; OUTPUT;

D O I：

10.1371/journal.pone.0061883

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Background: Several recently developed therapies targeting motor disabilities in stroke sufferers have shown to be more effective than standard neurorehabilitation approaches. In this context, several basic studies demonstrated that music training produces rapid neuroplastic changes in motor-related brain areas. Music-supported therapy has been recently developed as a new motor rehabilitation intervention. Methods and Results: In order to explore the plasticity effects of music-supported therapy, this therapeutic intervention was applied to twenty chronic stroke patients. Before and after the music-supported therapy, transcranial magnetic stimulation was applied for the assessment of excitability changes in the motor cortex and a 3D movement analyzer was used for the assessment of motor performance parameters such as velocity, acceleration and smoothness in a set of diadochokinetic movement tasks. Our results suggest that the music-supported therapy produces changes in cortical plasticity leading the improvement of the subjects' motor performance. Conclusion: Our findings represent the first evidence of the neurophysiological changes induced by this therapy in chronic stroke patients, and their link with the amelioration of motor performance. Further studies are needed to confirm our observations.

引用

页数：10

共 44 条

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Neural Reorganization Underlies Improvement in Stroke-induced Motor Dysfunction by Music-supported Therapy [J].