Clinical Review of Antidiabetic Drugs: Implications for Type 2 Diabetes Mellitus Management

被引：1060

作者：

Chaudhury, Arun ^{[1
]}

Duvoor, Chitharanjan ^{[1
,2
]}

Dendi, Vijaya Sena Reddy ^{[3
]}

Kraleti, Shashank ^{[2
]}

Chada, Aditya ^{[1
,2
]}

Ravilla, Rahul ^{[1
,2
]}

Marco, Asween ^{[1
,4
]}

Shekhawat, Nawal Singh ^{[1
,5
]}

Montales, Maria Theresa ^{[2
]}

Kuriakose, Kevin ^{[6
]}

Sasapu, Appalanaidu ^{[2
]}

Beebe, Alexandria ^{[7
]}

Patil, Naveen ^{[7
]}

Musham, Chaitanya K. ^{[8
]}

Lohani, Govinda Prasad ^{[9
]}

Mirza, Wasique ^{[10
]}

机构：

[1] GIM Fdn, Little Rock, AR 72210 USA

[2] Univ Arkansas Med Sci, Little Rock, AR 72205 USA

[3] Christus Trinity Mother Frances Hosp, Tyler, TX USA

[4] Univ Arkansas, Little Rock, AR 72204 USA

[5] Tutwiler Clin, Tutwiler, MS USA

[6] Vanderbilt Univ, 221 Kirkland Hall, Nashville, TN 37235 USA

[7] Arkansas Dept Hlth, Little Rock, AR 72205 USA

[8] St Vincent Infirm, Little Rock, AR USA

[9] Baptist Hosp SpringHill, North Little Rock, AR USA

[10] Wright Ctr Grad Med Educ, Scranton, PA USA

来源：

FRONTIERS IN ENDOCRINOLOGY | 2017年 / 8卷

关键词：

diabetes; clinical management; chronic; insulin; primary care; GLUCOSE-LOWERING DRUGS; CONSENSUS STATEMENT; ASSOCIATION; PATHOGENESIS; METFORMIN; GLYCEMIA; DISEASE;

D O I：

10.3389/fendo.2017.00006

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Type 2 diabetes mellitus (T2DM) is a global pandemic, as evident from the global cartographic picture of diabetes by the International Diabetes Federation (http://www.diabetesatlas.org/). Diabetes mellitus is a chronic, progressive, incompletely understood metabolic condition chiefly characterized by hyperglycemia. Impaired insulin secretion, resistance to tissue actions of insulin, or a combination of both are thought to be the commonest reasons contributing to the pathophysiology of T2DM, a spectrum of disease originally arising from tissue insulin resistance and gradually progressing to a state characterized by complete loss of secretory activity of the beta cells of the pancreas. T2DM is a major contributor to the very large rise in the rate of non-communicable diseases affecting developed as well as developing nations. In this mini review, we endeavor to outline the current management principles, including the spectrum of medications that are currently used for pharmacologic management, for lowering the elevated blood glucose in T2DM.

引用

页数：12

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