A prevalence study of celiac disease in persons with Down syndrome residing in the United States of America

被引：39

作者：

Pueschel, SM

Romano, C

Failla, P

Barone, C

Pettinato, R

Chiodo, AC

Plumari, DL

机构：

[1] Brown Univ, Rhode Isl Hosp, Sch Med, Child Dev Ctr, Providence, RI 02903 USA

[2] OASI Inst, Dept Pediat, Troina, Italy

[3] OASI Inst, Blood Chem Lab, Troina, Italy

来源：

ACTA PAEDIATRICA | 1999年 / 88卷 / 09期

关键词：

antiendomysium antibodies; celiac disease; Down syndrome; IgG and IgA antigliadin antibodies;

D O I：

10.1080/08035259950168432

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

In order to estimate the prevalence of celiac disease in persons with Down syndrome, 105 patients with this chromosomal disorder residing on the East Coast of the United States of America were enrolled in this study. IgA and IgG antigliadin antibodies (AGA) were determined using a fluorescent immunoenzymatic assay, and antiendomysium antibodies (AEA) were measured with immunofluorescence on monkey oesophagus. Of the 105 patients, 5 were positive for AEA, 4 were positive for IgG AGA, and 1 was positive for IgG ACA and AEA. Of the five patients with high titres of AEA, four consented to a jejunal biopsy, which revealed significant villous atrophy. Thus, 4 (possibly 5) patients in this cohort of 105 individuals with Down syndrome have celiac disease.

引用

页码：953 / 956

页数：4

共 28 条

[1]

BENTLEY D, 1975, PEDIATRICS, V56, P131

[2] Down syndrome and coeliac disease: Usefulness of antigliadin and antiendomysium antibodies [J].