Repeat administration of drugs as a means to assess the genetic component in pharmacological variability

被引:32
作者
Kalow, W [1 ]
Endrenyi, L [1 ]
Tang, BK [1 ]
机构
[1] Univ Toronto, Dept Pharmacol, Toronto, ON M5S 1A8, Canada
关键词
D O I
10.1159/000028292
中图分类号
R9 [药学];
学科分类号
1007 [药学];
摘要
引用
收藏
页码:281 / 284
页数:4
相关论文
共 13 条
[1]
INTRAINDIVIDUAL VARIATION IN DRUG DISPOSITION [J].
ALVARES, AP ;
KAPPAS, A ;
EISEMAN, JL ;
ANDERSON, KE ;
PANTUCK, CB ;
PANTUCK, EJ ;
HSIAO, KC ;
GARLAND, WA ;
CONNEY, AH .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 1979, 26 (04) :407-419
[2]
Antipyrine as a probe for human oxidative drug metabolism: Identification of the cytochrome P450 enzymes catalyzing 4-hydroxyantipyrine, 3-hydromethylantipyrine, and norantipyrine formation [J].
Engel, G ;
Hofmann, U ;
Heidemann, H ;
Cosme, J ;
Eichelbaum, M .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 1996, 59 (06) :613-623
[3]
Kalow W, 1998, PHARMACOGENETICS, V8, P283
[4]
Quantification of 3-month intraindividual variability and the influence of sex and menstrual cycle phase on CYP3A activity as measured by phenotyping with intravenous midazolam [J].
Kashuba, ADM ;
Bertino, JS ;
Rocci, ML ;
Kulawy, RW ;
Beck, DJ ;
Nafziger, AN .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 1998, 64 (03) :269-277
[5]
GENETIC-VARIATION IN RATES OF ANTIPYRINE METABOLITE FORMATION - A STUDY IN UNINDUCED TWINS [J].
PENNO, MB ;
DVORCHIK, BH ;
VESELL, ES .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (08) :5193-5196
[6]
Genetic anticipation: fact or artifact, genetics or epigenetics? [J].
Petronis, A ;
Kennedy, JL ;
Paterson, AD .
LANCET, 1997, 350 (9088) :1403-1404
[7]
Modification of clinical presentation of prostate tumors by a novel genetic variant in CYP3A4 [J].
Rebbeck, TR ;
Jaffe, JM ;
Walker, AH ;
Wein, AJ ;
Malkowicz, SB .
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1998, 90 (16) :1225-1229
[8]
Assays for CYP1A2 by testing in vivo metabolism of caffeine in humans [J].
Tang, BK ;
Kalow, W .
CYTOCHROME P450, PT B, 1996, 272 :124-131
[9]
GENETIC CONTROL OF DRUG LEVELS IN MAN - PHENYLBUTAZONE [J].
VESELL, ES ;
PAGE, JG .
SCIENCE, 1968, 159 (3822) :1479-&
[10]
GENETIC CONTROL OF DICUMAROL LEVELS IN MAN [J].
VESELL, ES ;
PAGE, JG .
JOURNAL OF CLINICAL INVESTIGATION, 1968, 47 (12) :2657-&