Air pollution and multiple acute respiratory outcomes

被引:126
作者
Faustini, Annunziata [1 ]
Stafoggia, Massimo [1 ]
Colais, Paola [1 ]
Berti, Giovanna [2 ]
Bisanti, Luigi [3 ]
Cadum, Ennio [2 ]
Cernigliaro, Achille [4 ]
Mallone, Sandra [5 ]
Scarnato, Corrado [6 ]
Forastiere, Francesco [1 ]
机构
[1] Reg Hlth Serv Lazio, Dept Epidemiol, I-00198 Rome, Italy
[2] Reg Environm Protect Agcy, Epidemiol Serv, Turin, Italy
[3] Local Hlth Author, Epidemiol Unit, Milan, Italy
[4] Reg Hlth Author, Epidemiol Observ, Palermo, Italy
[5] Ctr Canc Prevent, Florence, Italy
[6] Local Hlth Author, Bologna, Italy
关键词
OBSTRUCTIVE PULMONARY-DISEASE; CASE-CROSSOVER; HOSPITAL ADMISSIONS; PARTICULATE MATTER; SUSCEPTIBILITY FACTORS; AMBIENT PARTICLES; MORTALITY; ASTHMA; FINE; HEALTH;
D O I
10.1183/09031936.00128712
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Short-term effects of air pollutants on respiratory mortality and morbidity have been consistently reported but usually studied separately. To more completely assess air pollution effects, we studied hospitalisations for respiratory diseases together with out-of-hospital respiratory deaths. A time-stratified case-crossover study was carried out in six Italian cities from 2001 to 2005. Daily particulate matter (particles with a 50% cut-off aerodynamic diameter of 10 mu m (PM10)) and nitrogen dioxide (NO2) associations with hospitalisations for respiratory diseases (n=100 690), chronic obstructive pulmonary disease (COPD) (n=38 577), lower respiratory tract infections (LRTI) among COPD patients (n=9886) and out-of-hospital respiratory deaths (n=5490) were estimated for residents aged >= 35 years. For an increase of 10 mu g.m(-3) in PM10, we found., an immediate 0.59% (lag 0-1 days) increase in hospitalisations for respiratory diseases and a 0.67% increase for COPD; the 1.91% increase in LRTI hospitalisations lasted longer (lag 0-3 days) and the 3.95% increase in respiratory mortality lasted 6 days. Effects of NO2 were stronger and lasted longer (lag 0-5 days). Age, sex and previous ischaemic heart disease acted as effect modifiers for different outcomes. Analysing multiple rather than single respiratory events shows stronger air pollution effects. The temporal relationship between the pollutant increases and hospitalisations or mortality for respiratory diseases differs.
引用
收藏
页码:304 / 313
页数:10
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