Rapid in vivo hydrolysis of fatty acid ethyl esters, toxic nonoxidative ethanol metabolites

被引:45
作者
Saghir, M
Werner, J
Laposata, M
机构
[1] MASSACHUSETTS GEN HOSP, DIV CLIN LABS, BOSTON, MA 02114 USA
[2] MASSACHUSETTS GEN HOSP, DEPT PATHOL, BOSTON, MA 02114 USA
[3] MASSACHUSETTS GEN HOSP, DEPT SURG, BOSTON, MA 02114 USA
[4] HARVARD UNIV, SCH MED, BOSTON, MA 02114 USA
来源
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY | 1997年 / 273卷 / 01期
关键词
alcohol; pancreatitis; free fatty acid; omega-3 fatty acids;
D O I
10.1152/ajpgi.1997.273.1.G184
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Fatty acid ethyl esters (FAEE), esterification products of fatty acids and ethanol, are in use as fatty acid supplements, but they also have been implicated as toxic mediators of ethanol ingestion. We hypothesized that hydrolysis of orally ingested FAEE occurs in the gastrointestinal (GI) tract and in the blood to explain their apparent lack of toxicity. To study the in vivo inactivation of FAEE by hydrolysis to free fatty acids and ethanol, we assessed the hydrolysis of FAEE administered as an oil directly into the rat stomach and when injected within the core of low-density lipoprotein particles into the circulation of rats. Our studies demonstrate that FAEE are rapidly degraded to free fatty acids and ethanol in the GI tract at the level of the duodenum with Limited hydrolysis in the stomach. In addition, FAEE are rapidly degraded in the circulation, with a half-life of only 58 s. Thus the degradation of FAEE in the GI tract and in the blood provides an explanation for the apparent lack of toxicity of orally ingested FAEE.
引用
收藏
页码:G184 / G190
页数:7
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