Palladium-Catalyzed Cyclization/Carbonylation as a Direct Route to 4-[(Methoxycarbonyl)methyl]-3,4-dihydroisoquinolinones

被引：8

作者：

Ardizzoia, G. Attilio ^{[1
]}

Beccalli, Egle M. ^{[2
]}

Borsini, Elena ^{[1
]}

Brenna, Stefano ^{[1
]}

Broggini, Gianluigi ^{[1
]}

Rigamonti, Micol ^{[1
]}

机构：

[1] Univ Insubria, Dipartimento Sci Chim & Ambientali, I-22100 Como, Italy

[2] Univ Milan, Fac Farm, Ist Chim Organ A Marchesini, I-20133 Milan, Italy

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2008年 / 2008卷 / 33期

关键词：

Carbonylations; Cyclizations; Palladium; Nitrogen heterocycles;

D O I：

10.1002/ejoc.200800747

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient synthetic protocol for the preparation of 4-[(methoxycarbonyl)methyl]-3,4-dihydroisoquinolin-1-ones from N-allylamides of 2-iodobenzoic acids has been performed under 100 atm of carbon monoxide. Pyridine ring formation occurs through an intramolecular Pd-catalyzed carbon-carbon bond formation, followed by an alkoxycarbonylation process. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)

引用

页码：5590 / 5596

页数：7

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