Expression of aromatase (P450 aromatase/CYP19) in peritoneal and ovarian endometriotic tissues and deep endometriotic (adenomyotic) nodules of the rectovaginal septum

被引：54

作者：

Heilier, Jean-Francois

Donnez, Olivier

Van Kerckhove, Valerie

Lison, Dominique

Donnez, Jacqucs

机构：

[1] Catholic Univ Louvain, Ind Toxicol & Occupat Med Unit, Fac Med, B-1200 Brussels, Belgium

[2] Clin Univ St Luc, Dept Gynaecol, B-1200 Brussels, Belgium

[3] Catholic Univ Louvain, Gynaecol Unit, B-1200 Brussels, Belgium

来源：

FERTILITY AND STERILITY | 2006年 / 85卷 / 05期

关键词：

D O I：

10.1016/j.fertnstert.2005.10.041

中图分类号：

R71 [妇产科学];

学科分类号：

100211 [妇产科学];

摘要：

We found, by reverse transcription-real time-polymerase chain reaction, that the expression of aromatase (CYP19) in ovarian, peritoneal endometriosis, and deep endometriotic nodules is significantly different, which strengthens the theory of three distinct clinical entities. Compared with peritoneal endometriosis, ovarian endometriosis exhibits an 8-fold higher expression of aromatase, which suggests that aromatase inhibitors may be particularly active in this form of endometriosis.

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页码：1516 / 1518

页数：3

相关论文

共 8 条

[1]

High endometrial aromatase P450 mRNA expression is associated with poor IVF outcome [J].

Brosens, J ;

Verhoeven, H ;

Campo, R ;

Gianaroli, L ;

Gordts, S ;

Hazekamp, J ;

Hägglund, L ;

Mardesic, T ;

Varila, E ;

Zech, J ;

Brosens, I .

HUMAN REPRODUCTION, 2004, 19 (02) :352-356

[2]

Peritoneal endometriosis and ''endometriotic'' nodules of the rectovaginal septum are two different entities [J].

Donnez, J ;

Nisolle, M ;

Smoes, P ;

Gillet, N ;

Beguin, S ;

CasanasRoux, F .

FERTILITY AND STERILITY, 1996, 66 (03) :362-368

[3]

Gonadotropin-releasing hormone agonist and danazol normalize aromatase cytochrome P450 expression in eutopic endometrium from women with endometriosis, adenomyosis, or leiomyomas [J].

Ishihara, H ;

Kitawaki, J ;

Kado, N ;

Koshiba, H ;

Fushiki, S ;

Honjo, H .

FERTILITY AND STERILITY, 2003, 79 :735-742

[4]

Endometriosis: the pathophysiology as an estrogen-dependent disease [J].

Kitawaki, J ;

Kado, N ;

Ishihara, H ;

Koshiba, H ;

Kitaoka, Y ;

Honjo, H .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2002, 83 (1-5) :149-155

[5]

Peritoneal endometriosis, ovarian endometriosis, and adenomyotic nodules of the rectovaginal septum are three different entities [J].

Nisolle, M ;

Donnez, J .

FERTILITY AND STERILITY, 1997, 68 (04) :585-596

[6]

Aromatase expression in endometriosis [J].

Noble, LS ;

Simpson, ER ;

Johns, A ;

Bulun, SE .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1996, 81 (01) :174-179

[7]

New medical treatments for endometriosis [J].

Olive, DL ;

Lindheim, SR ;

Pritts, EA .

BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY, 2004, 18 (02) :319-328

[8]

AROMATASE CYTOCHROME-P450, THE ENZYME RESPONSIBLE FOR ESTROGEN BIOSYNTHESIS [J].

SIMPSON, ER ;

MAHENDROO, MS ;

MEANS, GD ;

KILGORE, MW ;

HINSHELWOOD, MM ;

GRAHAMLORENCE, S ;

AMARNEH, B ;

ITO, YJ ;

FISHER, CR ;

MICHAEL, MD ;

MENDELSON, CR ;

BULUN, SE .

ENDOCRINE REVIEWS, 1994, 15 (03) :342-355