Sphingosine 1-phosphate signalling

被引：266

作者：

Mendelson, Karen ^{[1
]}

Evans, Todd ^{[1
]}

Hla, Timothy ^{[1
]}

机构：

[1] Cornell Univ, Weill Cornell Med Coll, New York, NY 10065 USA

来源：

DEVELOPMENT | 2014年 / 141卷 / 01期

基金：

美国国家卫生研究院;

关键词：

S1P receptors; Sphingosine-1-phosphate; Sphingomyelin; PROTEIN-COUPLED RECEPTOR; SPHINGOSINE-1-PHOSPHATE RECEPTORS; LYMPHOCYTE EGRESS; CELL-MIGRATION; SPROUTING ANGIOGENESIS; INTERNATIONAL UNION; PROGENITOR CELLS; ORAL FINGOLIMOD; EDG-1; TRAFFICKING;

D O I：

10.1242/dev.094805

中图分类号：

Q [生物科学];

学科分类号：

090105 [作物生产系统与生态工程];

摘要：

Sphingosine 1-phosphate (S1P) is a lipid mediator formed by the metabolism of sphingomyelin. In vertebrates, S1P is secreted into the extracellular environment and signals via G protein-coupled S1P receptors to regulate cell-cell and cell-matrix adhesion, and thereby influence cell migration, differentiation and survival. The expression and localization of S1P receptors is dynamically regulated and controls vascular development, vessel stability and immune cell trafficking. In addition, crucial events during embryogenesis, such as angiogenesis, cardiogenesis, limb development and neurogenesis, are regulated by S1P signalling. Here, and in the accompanying poster, we provide an overview of S1P signalling in development and in disease.

引用

页码：5 / 9

页数：5

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