Interleukin-6 (IL-6):: A possible neuromodulator induced by neuronal activity

被引：113

作者：

Jüttler, E ^{[1
]}

Tarabin, V ^{[1
]}

Schwaninger, M ^{[1
]}

机构：

[1] Univ Heidelberg, Dept Neurol, D-69120 Heidelberg, Germany

来源：

NEUROSCIENTIST | 2002年 / 8卷 / 03期

关键词：

interleukin-6; membrane depolarization; cerebral ischemia; fever; depression; neuroprotection;

D O I：

10.1177/1073858402008003012

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

IL-6 and its receptor(s) are found in the CNS in health and disease. Cellular sources are glial cells and neurons. Glial production of IL-6 has intensively been studied, but comparatively little is known about the induction of IL-6 in neurons. Emerging evidence suggests that IL-6 possesses neurotrophic properties. Recent data show that neuronal IL-6 expression is induced by excitatory amino acids or membrane depolarization. This implicates that IL-6 is produced not only under pathological conditions but may play a critical role as a physiological neuromodulator that is induced by neuronal activity and regulates brain functions. In the following article, the authors review the current data on IL-6 expression in neurons, with special reference to the induction of IL-6 by neuronal activity. They discuss its direct and indirect effects as a neuromodulator and speculate about the possible function of IL-6 as a physiological regulatory molecule and as a neuroprotective agent in brain pathology.

引用

页码：268 / 275

页数：8

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