The effect of the menstrual cycle on human cerebral blood flow: studies using Doppler ultrasound

被引:36
作者
Brackley, KJ [1 ]
Ramsay, MM [1 ]
Pipkin, FB [1 ]
Rubin, PC [1 ]
机构
[1] Univ Nottingham, Queens Med Ctr, Sch Med, Dept Obstet & Gynaecol, Nottingham NG7 2RD, England
关键词
Doppler ultrasound; cerebral blood flow; menstrual cycle;
D O I
10.1046/j.1469-0705.1999.14010052.x
中图分类号
O42 [声学];
学科分类号
070206 ; 082403 ;
摘要
Objective Previous studies have demonstrated hemodynamic changes nt different phases ill the menstrual cycle, bur the cerebral circulation has not been investigated. Our aim was,as to study carotid and cerebral blood flow during the menstrual cycle using Doppler ultrasound. Two different techniques of Doppler waveform analysis were used: standard Doppler indices and Laplace transform analysis (LTA), which may provide additional hemodynamic information. Design This was a prospective study of healthy volunteers who were providing pre-conception data for a subsequent longitudinal study set in the Department of Obstetrics and Gynaecology, Nottingham University Hospital. Nineteen women rr,ere studied in the mid-follicular and mid-luteal phases of 27 ovulatory menstrual cycles. Doppler recordings were obtained from the internal and external carotid and middle cerebral arteries. The standard Doppler indices (systolic/diastolic ratio, pulsatility index and resistance index) and LTA paramaters were calculated. Results The standard Doppler indices were all significantly higher ill the luteal compared to the follicular phase in the right middle cerebral artery (p < 0.05). However, no changes were seen in the standard indices in the carotid arteries or in any of the LTA parameters in any artery! Using the LTA, vessel wall stiffness was greater and absolute velocity,of flow lower in the middle cerebral compared to the carotin arteries. Conclusions Increased ventilation and a subsequent lowering of alveolar CO2 pressure secondary to a raised progesterone level ill the mid-luteal phase could account for the observed changes within the middle cerebral artery. Under the conditions of this study the LTA appears less sensitive at defecting alterations in downstream resistance compared to the standard Doppler indices.
引用
收藏
页码:52 / 57
页数:6
相关论文
共 41 条
[1]   NON-INVASIVE TRANSCRANIAL DOPPLER ULTRASOUND RECORDING OF FLOW VELOCITY IN BASAL CEREBRAL-ARTERIES [J].
AASLID, R ;
MARKWALDER, TM ;
NORNES, H .
JOURNAL OF NEUROSURGERY, 1982, 57 (06) :769-774
[2]   CHANGES IN SKIN BLOOD-FLOW DURING THE MENSTRUAL-CYCLE - THE INFLUENCE OF THE MENSTRUAL-CYCLE ON THE PERIPHERAL-CIRCULATION IN HEALTHY FEMALE VOLUNTEERS [J].
BARTELINK, ML ;
WOLLERSHEIM, H ;
THEEUWES, A ;
VANDUREN, D ;
THIEN, T .
CLINICAL SCIENCE, 1990, 78 (05) :527-532
[3]   A longitudinal study of maternal bloodflow in normal pregnancy and the puerperium: analysis of Doppler waveforms using Laplace transform techniques [J].
Brackley, KJ ;
Ramsay, MM ;
Pipkin, FB ;
Rubin, PC .
BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 1998, 105 (01) :68-77
[4]  
BRACKLEY KJ, 1997, THESIS U NOTTINGHAM
[5]   Laser doppler-recorded reactive hyperaemia in the forearm skin during the menstrual cycle [J].
Bungum, L ;
Kvernebo, K ;
Oian, P ;
Maltau, JM .
BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 1996, 103 (01) :70-75
[6]   CHANGES IN BLOOD-PRESSURE DURING THE NORMAL MENSTRUAL-CYCLE [J].
DUNNE, FP ;
BARRY, DG ;
FERRISS, JB ;
GREALY, G ;
MURPHY, D .
CLINICAL SCIENCE, 1991, 81 (04) :515-518
[7]  
DUTTON K, 1989, J APPL PHYSIOL, V67, P517
[8]   FLUCTUATIONS IN ALVEOLAR CO-2 AND IN BASE EXCESS DURING MENSTRUAL-CYCLE [J].
ENGLAND, SJ ;
FARHI, LE .
RESPIRATION PHYSIOLOGY, 1976, 26 (02) :157-161
[9]  
EVANS D H, 1981, Clinical Physics and Physiological Measurement, V2, P17, DOI 10.1088/0143-0815/2/1/004
[10]   FETAL UMBILICAL ARTERY FLOW VELOCITY WAVEFORMS AND PLACENTAL RESISTANCE - PATHOLOGICAL CORRELATION [J].
GILES, WB ;
TRUDINGER, BJ ;
BAIRD, PJ .
BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 1985, 92 (01) :31-38