Cancer systems biology in the genome sequencing era: Part 2, evolutionary dynamics of tumor clonal networks and drug resistance

被引：58

作者：

Wang, Edwin ^{[1
,2
]}

Zou, Jinfeng ^{[1
,3
,4
]}

Zaman, Naif ^{[1
,5
]}

Beitel, Lenore K. ^{[3
,4
]}

Trifiro, Mark ^{[3
,4
]}

Paliouras, Miltiadis ^{[3
,4
]}

机构：

[1] Natl Res Council Canada, Montreal, PQ, Canada

[2] McGill Univ, Ctr Bioinformat, Montreal, PQ, Canada

[3] Lady Davis Inst, Montreal, PQ, Canada

[4] McGill Univ, Dept Med, Montreal, PQ, Canada

[5] McGill Univ, Dept Anat & Cell Biol, Montreal, PQ, Canada

来源：

SEMINARS IN CANCER BIOLOGY | 2013年 / 23卷 / 04期

基金：

加拿大健康研究院;

关键词：

Genome sequencing; Systems biology; Signaling network; Cancer evolution; Tumor heterogeneity; Tumor clone; Drug resistance; Early-warning signal; Personalized medicine; GENE REGULATORY NETWORKS; ROBUSTNESS; FEEDBACK; RECONSTRUCTION; IDENTIFICATION; PERTURBATIONS; BISTABILITY; MUTATIONS; PROTEINS; HOTSPOTS;

D O I：

10.1016/j.semcancer.2013.06.001

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A tumor often consists of multiple cell subpopulations (clones). Current chemo-treatments often target one clone of a tumor. Although the drug kills that clone, other clones overtake it and the tumor recurs. Genome sequencing and computational analysis allows to computational dissection of clones from tumors, while singe-cell genome sequencing including RNA-Seq allows profiling of these clones. This opens a new window for treating a tumor as a system in which clones are evolving. Future cancer systems biology studies should consider a tumor as an evolving system with multiple clones. Therefore, topics discussed in Part 2 of this review include evolutionary dynamics of clonal networks, early-warning signals (e.g., genome duplication events) for formation of fast-growing clones, dissecting tumor heterogeneity, and modeling of clone-clone-stroma interactions for drug resistance. The ultimate goal of the future systems biology analysis is to obtain a 'whole-system' understanding of a tumor and therefore provides a more efficient and personalized management strategies for cancer patients. Crown Copyright (C) 2013 Published by Elsevier Ltd. All rights reserved.

引用

页码：286 / 292

页数：7

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