A one-year study on the pharmacodynamic profile of interferon-β1a in MS

被引：12

作者：

Bagnato, F

Pozzilli, C

Scagnolari, C

Bellomi, F

Pasqualetti, P

Gasperini, C

Millefiorini, E

Galgani, S

Spadaro, M

Antonelli, G

机构：

[1] Univ Roma La Sapienza, Dept Neurol Sci, I-00185 Rome, Italy

[2] Univ Roma La Sapienza, Dept Expt Med & Pathol, Virol Sect, I-00185 Rome, Italy

[3] San Camillo Hosp, Neurol Sect, Rome, Italy

[4] Univ Roma La Sapienza, Inst Neurol, Rome, Italy

来源：

NEUROLOGY | 2002年 / 58卷 / 09期

关键词：

D O I：

10.1212/WNL.58.9.1409

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Interferon (IFN)-beta1a induction of neopterin and beta2-microglobulin (beta2-MG) were evaluated over 1 year in patients with MS. Neopterin and beta2-MG levels peaked 24 to 48 hours after weekly injections of IFNbeta1a over the entire study period. Predose levels of neopterin decreased significantly, consistent with a long-term decrease in IFNgamma expression and macrophage activation during IFNbeta-1a treatment. Predose levels of beta2-MG increased, the significance of which is as yet unclear.

引用

页码：1409 / 1411

页数：3

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