A New Scale Measuring Psychologic Impact of Genetic Susceptibility Testing for Alzheimer Disease

被引：28

作者：

Chung, Winston W. ^{[1
]}

Chen, Clara A. ^{[5
]}

Cupples, L. Adrienne ^{[3
,4
]}

Roberts, J. Scott ^{[6
]}

Hiraki, Susan C. ^{[1
]}

Nair, Anil K. ^{[1
]}

Green, Robert C. ^{[1
,2
,4
]}

Stern, Robert A. ^{[1
]}

机构：

[1] Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA

[2] Boston Univ, Sch Med, Dept Med, Genet Program, Boston, MA 02118 USA

[3] Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02118 USA

[4] Boston Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02118 USA

[5] Boston Univ, Sch Publ Hlth, Data Coordinating Ctr, Boston, MA 02118 USA

[6] Univ Michigan, Sch Publ Hlth, Dept Hlth Behav & Hlth Educ, Ann Arbor, MI 48109 USA

来源：

ALZHEIMER DISEASE & ASSOCIATED DISORDERS | 2009年 / 23卷 / 01期

关键词：

Alzheimer disease genetics; genetic testing; Alzheimer disease risk assessment; BECK ANXIETY INVENTORY; EVENT SCALE; PSYCHOMETRIC EVALUATION; ASSOCIATION; INFORMATION; STATEMENT; DISTRESS; CANCER;

D O I：

10.1097/WAD.0b013e318188429e

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

This paper describes the development and psychometric properties of it new scale for assessing the psychologic impact of genetic susceptibility testing for Alzheimer disease (AD). The new instrument. The REVEAL Impact of Genetic Testing for Alzheimer's disease (IGT-AD) was designed to examine the unique nature of genetic information and the disease course of AD. The scale was tested its it part of a multicenter clinical trial designed to evaluate the impact of AD risk assessment and data were collected from 276 participants in the study. Using ail iterative process of principal component analysis and Cronbach alpha, the final 16-item IGT-AD Was found to have a 2-factor structure with excellent internal reliability. Construct validity was established by patterns of correlation with other standardized self-reported measures. This scale should be useful in the identification of patients who maybe susceptible to the negative effects of receiving genetic information, monitoring of patients who have received genetic information, and its a tool for researchers who wish to study the effects of genetic susceptibility testing for AD.

引用

页码：50 / 56

页数：7

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