Exported proteins in probiotic bacteria:: adhesion to intestinal surfaces, host immunomodulation and molecular cross-talking with the host

被引:112
作者
Sanchez, Borja [1 ]
Bressollier, Philippe [1 ,2 ]
Urdaci, Maria C. [1 ]
机构
[1] Univ Bordeaux 1, CBMN, UMR 5248,CNRS, Lab Microbiol & Biochim Appl,ENITAB, F-33175 Gradignan, France
[2] Dept Gen Biol, Lab Chim Subst Nat, Limoges, France
来源
FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY | 2008年 / 54卷 / 01期
关键词
probiotics; surface proteins; host interaction; secreted proteins; adhesion; immunomodulation;
D O I
10.1111/j.1574-695X.2008.00454.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The group of exported proteins of a bacterium are those proteins that are sorted from the cytoplasm to the bacterial surface or to the surroundings of the microorganism. In probiotic bacteria, these proteins are of special relevance because they might determine important traits such as adhesion to intestinal surfaces and molecular cross-talking with the host. Current knowledge about the presence and biological relevance of exported proteins produced by the main genera of probiotic bacteria in the gastrointestinal environment is reviewed in this minireview. As will be seen, some of these proteins are involved in host adhesion or are able to modify certain signalization pathways within host cells, whereas others are important for the physiology of probiotic bacteria in the gastrointestinal tract.
引用
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页码:1 / 17
页数:17
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