Interhemispheric correlations of slow spontaneous neuronal fluctuations revealed in human sensory cortex

被引:358
作者
Nir, Yuval [1 ]
Mukamel, Roy [2 ,3 ]
Dinstein, Ilan [4 ]
Privman, Eran [5 ]
Harel, Michal [1 ]
Fisch, Lior [1 ]
Gelbard-Sagiv, Hagar [1 ]
Kipervasser, Svetlana [6 ,7 ]
Andelman, Fani [8 ]
Neufeld, Miri Y. [6 ,7 ]
Kramer, Uri [6 ,8 ]
Arieli, Amos [1 ]
Fried, Itzhak [2 ,3 ,6 ,8 ]
Malach, Rafael [1 ]
机构
[1] Weizmann Inst Sci, Dept Neurobiol, IL-76100 Rehovot, Israel
[2] Univ Calif Los Angeles, David Geffen Sch Med, Div Neurosurg, Los Angeles, CA 90095 USA
[3] Univ Calif Los Angeles, Semel Inst Neurosci & Human Behav, Los Angeles, CA 90095 USA
[4] NYU, Ctr Neural Sci, New York, NY 10003 USA
[5] Tel Aviv Univ, Sackler Fac Exact Sci, Sch Comp Sci, IL-69978 Tel Aviv, Israel
[6] Tel Aviv Univ, Sackler Sch Med, IL-69978 Tel Aviv, Israel
[7] Tel Aviv Med Ctr & Sch Med, Dept Neurol, Electroencephalog & Epilepsy Unit, IL-64239 Tel Aviv, Israel
[8] Tel Aviv Med Ctr & Sch Med, Funct Neurosurg Unit, IL-64239 Tel Aviv, Israel
基金
以色列科学基金会;
关键词
D O I
10.1038/nn.2177
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Animal studies have shown robust electrophysiological activity in the sensory cortex in the absence of stimuli or tasks. Similarly, recent human functional magnetic resonance imaging (fMRI) revealed widespread, spontaneously emerging cortical fluctuations. However, it is unknown what neuronal dynamics underlie this spontaneous activity in the human brain. Here we studied this issue by combining bilateral single-unit, local field potentials (LFPs) and intracranial electrocorticography (ECoG) recordings in individuals undergoing clinical monitoring. We found slow (<0.1 Hz, following 1/f-like profiles) spontaneous fluctuations of neuronal activity with significant interhemispheric correlations. These fluctuations were evident mainly in neuronal firing rates and in gamma (40-100 Hz) LFP power modulations. Notably, the interhemispheric correlations were enhanced during rapid eye movement and stage 2 sleep. Multiple intracranial ECoG recordings revealed clear selectivity for functional networks in the spontaneous gamma LFP power modulations. Our results point to slow spontaneous modulations in firing rate and gamma LFP as the likely correlates of spontaneous fMRI fluctuations in the human sensory cortex.
引用
收藏
页码:1100 / 1108
页数:9
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