Balancing instability: dual roles for telomerase and telomere dysfunction in tumorigenesis

被引：200

作者：

Hackett, JA

Greider, CW

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Mol Biol & Genet, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Predoctoral Training Program Human Genet & Mol Bi, Baltimore, MD 21205 USA

来源：

ONCOGENE | 2002年 / 21卷 / 04期

关键词：

telomeres; telomerase; chromosomal instability;

D O I：

10.1038/sj.onc.1205061

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Telomere shortening and telomerase activation both occur in human tumors. Telomere shortening has been proposed to have two conflicting roles in tumorigenesis: tumor suppression and initiation of chromosomal instability. Similarly, while telomerase activation is suggested to be necessary for tumor growth, telomerase may help to stabilize genomic instability. Here we review what is known about these conflicting roles and propose a framework to understand the role of telomerase in cancer progression.

引用

收藏

页码：619 / 626

页数：8

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