A putative precursor of isomalabaricane triterpenoids from lanosterol synthase mutants

被引：35

作者：

Lodeiro, S

Wilson, WK

Shan, H

Matsuda, SPT

机构：

[1] Rice Univ, Dept Chem, Houston, TX 77005 USA

[2] Rice Univ, Dept Biochem & Cell Biol, Houston, TX 77005 USA

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 03期

关键词：

D O I：

10.1021/ol052725j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Known lanosterol synthase mutants produce monocyclic or tetracyclic byproducts from oxidosqualene. We describe Erg7 Tyr510 mutants that cause partial substrate misfolding and generate a tricyclic byproduct. This novel triterpene, (13 alpha H)-isomalabarica-14(27),17E,21-trien-3 beta-ol, is the likely biosynthetic precursor of isomalabaricane triterpenoids in sponges. The results suggest the facile evolution of protective triterpenoids in sessile animals.

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页码：439 / 442

页数：4

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