Reproducibility of Dynamic Contrast-enhanced MR Imaging Part II. Comparison of Intra- and Interobserver Variability with Manual Region of Interest Placement versus Semiautomatic Lesion Segmentation and Histogram Analysis

被引：132

作者：

Heye, Tobias ^{[1
]}

Merkle, Elmar M. ^{[3
]}

Reiner, Caecilia S. ^{[1
]}

Davenport, Matthew S. ^{[4
]}

Horvath, Jeffrey J. ^{[1
]}

Feuerlein, Sebastian ^{[5
]}

Breault, Steven R. ^{[1
]}

Gall, Peter ^{[6
]}

Bashir, Mustafa R. ^{[1
]}

Dale, Brian M. ^{[7
]}

Kiraly, Atilla P. ^{[8
]}

Boll, Daniel T. ^{[1
,2
]}

机构：

[1] Duke Univ, Med Ctr, Dept Radiol, Durham, NC 27710 USA

[2] Duke Univ, Med Ctr, Duke Multidimens Image Proc Lab, Durham, NC 27710 USA

[3] Univ Spital Basel, Dept Radiol & Nucl Med, Basel, Switzerland

[4] Univ Michigan Hlth Syst, Dept Radiol, Ann Arbor, MI USA

[5] Univ Virginia Hlth Syst, Dept Radiol & Med Imaging, Charlottesville, VA USA

[6] Siemens AG, Healthcare Sect, Imaging & Therapy Div, Erlangen, Germany

[7] Siemens Healthcare, MR R&D Collaborat, Morrisville, NC USA

[8] Siemens Corp Res, Princeton, NJ USA

来源：

RADIOLOGY | 2013年 / 266卷 / 03期

关键词：

INTRAOBSERVER VARIABILITY; CLINICAL-TRIALS; BREAST-CANCER; PERFUSION; TUMORS; PARAMETERS; PERMEABILITY; CHEMOTHERAPY; THERAPIES; PREDICT;

D O I：

10.1148/radiol.12120255

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

100231 [临床病理学]; 100902 [航空航天医学];

摘要：

Purpose: To compare the inter-and intraobserver variability with manual region of interest (ROI) placement versus that with software-assisted semiautomatic lesion segmentation and histogram analysis with respect to quantitative dynamic contrast material-enhanced (DCE) MR imaging determinations of the volume transfer constant (K-trans). Materials and Methods: The study was approved by the institutional review board and compliant with HIPAA. The requirement to obtain informed consent was waived. Fifteen DCE MR imaging studies of the female pelvis defined the study group. Uterine fibroids were used as a perfusion model. Three varying types of lesion measurements were performed by five readers on each study by using DCE MR imaging perfusion analysis software with manual ROI placement and a semiautomatic lesion segmentation and histogram analysis solution. Intra-and interreader variability of measurements of K-trans with the different measurement types was calculated. \Results: The overall interobserver variability of K-trans with manual ROI placement (mean, 28.5% +/- 6 9.3) was reduced by 42.5% when the semiautomatic, software-assisted lesion measurement method was used (16.4% +/- 6 6.2). Wholelesion measurement showed the lowest interobserver variability with both measurement methods (20.1% +/- 6 4.3 with the manual method vs 10.8% +/- 6 2.6 with the semiautomatic method). The overall intrareader variability with the manual ROI method (7.6% +/- 6 10.6) was not significantly different from that with the semiautomatic method (7.3% +/- 10.8), but the intraclass correlation coefficient for intrareader reproducibility improved from 0.86 overall with the manual method to 0.99 with the semiautomatic method. Conclusion: A semiautomatic lesion segmentation and histogram analysis approach can provide a significant reduction in interobserver variability for DCE MR imaging measurements of K-trans when compared with manual ROI methods, whereas intraobserver reproducibility is improved to some extent. (C) RSNA, 2012

引用

页码：812 / 821

页数：10

共 29 条

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Early Changes in Functional Dynamic Magnetic Resonance Imaging Predict for Pathologic Response to Neoadjuvant Chemotherapy in Primary Breast Cancer [J].