Nerve length and volume in synaptic vs diffusion neurotransmission: A model

NON-SYNAPTIC diffusion neurotransmission (NDN) may be an important factor in brain space and energy conservation, especially within cell assemblies and for mass sustained functions. We have illustrated the extreme cases of total synaptic and total ND neurotransmission for the purpose of noting the differences between the two. For these modeling studies, in which we assume assemblies of 1000 to 100 000 cells supplied by at least one fiber and a single synapse from each of the other cells, each cell assembly would have approximately 200 m to 8000 km of nerve fibers more than when innervated by diffusion. For coeruleo-cortical synaptic innervation, linking each to a common origin (the locus coeruelus), the fiber lengths are 38 cm (1000 cells) to 170 m (100 000 cells), It is likely, however, that neuronal arrays include both `wireless' (NDN) as well as synaptic intercellular communication systems.