Exploiting current understanding of antibiotic action for discovery of new drugs

[1] SPECIFICITY OF THE URIDINE-DIPHOSPHATE-N-ACETYLMURAMYL-L-ALANYL-D-GLUTAMATE - MESO-2,6-DIAMINOPIMELATE SYNTHETASE FROM ESCHERICHIA-COLI [J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1985, 153 (01): : 81 - 87

[2] EXTENSIVE HOMOLOGY AMONG THE LARGEST SUBUNITS OF EUKARYOTIC AND PROKARYOTIC RNA-POLYMERASES [J]. CELL, 1985, 42 (02) : 599 - 610

[3] NEW ANTIBIOTIC THAT ACTS SPECIFICALLY ON THE GTP-BOUND FORM OF ELONGATION FACTOR-TU [J]. EMBO JOURNAL, 1991, 10 (04) : 779 - 784

[4] INITIATION BY DNA-DEPENDENT RNA POLYMERASE [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1966, 56 (03) : 1026 - &

[5] Characterization of mutations in the rpoB gene that confer rifampin resistance in Staphylococcus aureus [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1998, 42 (10) : 2590 - 2594

[6] Synthesis and activity of analogues of SB-219383: Novel potent inhibitors of bacterial tyrosyl tRNA synthetase [J]. JOURNAL OF ANTIBIOTICS, 2000, 53 (11) : 1282 - 1292

[7] Crystal structure of UDP-N-acetylmuramoyl-L-alanine: D-glutamate ligase from Escherichia coli [J]. EMBO JOURNAL, 1997, 16 (12) : 3416 - 3425

[8] New agents for Gram-positive bacteria [J]. CURRENT OPINION IN MICROBIOLOGY, 2000, 3 (05) : 528 - 534

[9] Black T, 2000, CURR OPIN MICROBIOL, V3, P522, DOI 10.1016/S1369-5274(00)00133-8

[10] Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics [J]. NATURE, 2000, 407 (6802) : 340 - 348

[1] SPECIFICITY OF THE URIDINE-DIPHOSPHATE-N-ACETYLMURAMYL-L-ALANYL-D-GLUTAMATE - MESO-2,6-DIAMINOPIMELATE SYNTHETASE FROM ESCHERICHIA-COLI [J]. EUROPEAN JOURNAL OF BIOCHEMISTRY, 1985, 153 (01): : 81 - 87

[2] EXTENSIVE HOMOLOGY AMONG THE LARGEST SUBUNITS OF EUKARYOTIC AND PROKARYOTIC RNA-POLYMERASES [J]. CELL, 1985, 42 (02) : 599 - 610

[3] NEW ANTIBIOTIC THAT ACTS SPECIFICALLY ON THE GTP-BOUND FORM OF ELONGATION FACTOR-TU [J]. EMBO JOURNAL, 1991, 10 (04) : 779 - 784

[4] INITIATION BY DNA-DEPENDENT RNA POLYMERASE [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1966, 56 (03) : 1026 - &

[5] Characterization of mutations in the rpoB gene that confer rifampin resistance in Staphylococcus aureus [J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1998, 42 (10) : 2590 - 2594

[6] Synthesis and activity of analogues of SB-219383: Novel potent inhibitors of bacterial tyrosyl tRNA synthetase [J]. JOURNAL OF ANTIBIOTICS, 2000, 53 (11) : 1282 - 1292

[7] Crystal structure of UDP-N-acetylmuramoyl-L-alanine: D-glutamate ligase from Escherichia coli [J]. EMBO JOURNAL, 1997, 16 (12) : 3416 - 3425

[8] New agents for Gram-positive bacteria [J]. CURRENT OPINION IN MICROBIOLOGY, 2000, 3 (05) : 528 - 534

[9] Black T, 2000, CURR OPIN MICROBIOL, V3, P522, DOI 10.1016/S1369-5274(00)00133-8

[10] Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics [J]. NATURE, 2000, 407 (6802) : 340 - 348