Getting balance: Drugs for bipolar disorder share target

被引：21

作者：

Coyle, JT ^{[1
]}

Manji, HK

机构：

[1] Harvard Univ, Sch Med, McLean Dept Psychiat, Belmont, MA 02178 USA

[2] NIMH, Bethesda, MD 20892 USA

来源：

NATURE MEDICINE | 2002年 / 8卷 / 06期

关键词：

D O I：

10.1038/nm0602-557

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lithium and anticonvulsants such as valproic acid have the same end result: a more stable life for people with bipolar disorder. Now it seems they may also affect the same biochemical pathway in the brain.

引用

页码：557 / 558

页数：2

共 11 条

[1] NEURAL AND DEVELOPMENTAL ACTIONS OF LITHIUM - A UNIFYING HYPOTHESIS [J].

BERRIDGE, MJ ;

DOWNES, CP ;

HANLEY, MR .

CELL, 1989, 59 (03) :411-419

[2]

CHEN G, IN PRESS BIOL PSYCHI

[3] Neuroimaging and neuropathological studies of depression: implications for the cognitive-emotional features of mood disorders [J].

Drevets, WC .

CURRENT OPINION IN NEUROBIOLOGY, 2001, 11 (02) :240-249

[4] Synaptic plasticity and mood disorders [J].

Duman, RS .

MOLECULAR PSYCHIATRY, 2002, 7 (Suppl 1) :S29-S34

[5] A molecular mechanism for the effect of lithium on development [J].

Klein, PS ;

Melton, DA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (16) :8455-8459

[6]

Lenox RH, 2000, J CLIN PSYCHIAT, V61, P5

[7] ALTERATIONS IN PLASMA PROLYL ENDOPEPTIDASE ACTIVITY IN DEPRESSION, MANIA, AND SCHIZOPHRENIA - EFFECTS OF ANTIDEPRESSANTS, MOOD STABILIZERS, AND ANTIPSYCHOTIC-DRUGS [J].

MAES, M ;

GOOSSENS, F ;

SCHARPE, S ;

CALABRESE, J ;

DESNYDER, R ;

MELTZER, HY .

PSYCHIATRY RESEARCH, 1995, 58 (03) :217-225

[8] PKC, MAP kinases and the bcl-2 family of proteins as long-term targets for mood stabilizers [J].

Manji, HK ;

Chen, G .

MOLECULAR PSYCHIATRY, 2002, 7 (Suppl 1) :S46-S56

[9] Convergent functional genomics: application to bipolar disorder [J].

Niculescu, AB ;

Kelsoe, JR .

ANNALS OF MEDICINE, 2001, 33 (04) :263-271

[10] N-ACETYLASPARTATE IN NEUROPSYCHIATRIC DISORDERS [J].

TSAI, GC ;

COYLE, JT .

PROGRESS IN NEUROBIOLOGY, 1995, 46 (05) :531-540

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