A novel convenient route to the naturally occurring 3-oxoacyl-L-homoserinelactones and related bacterial autoinducers

被引：17

作者：

Dekhane, M

Douglas, KT

Gilbert, P

机构：

[1] Department of Pharmacy, University of Manchester, Manchester

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 11期

关键词：

D O I：

10.1016/0040-4039(96)00142-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The naturally occurring 3-oxohexanoyl-L-homoserinelactone (1a), a bacterial autoinducer, has been prepared in 47 % overall yield by condensing stable 3-oxohexanoic acid (2), prepared by hydrolysis from the corresponding ester (3), with L-homoserinelactone using hydroxybenzotriazole (HOBT) and dicyclohexylcarbodiimide (DCC) in non-aqueous media.

引用

页码：1883 / 1884

页数：2

共 11 条

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