A single-nucleotide polymorphism in MMP9 is associated with decreased risk of steroid-induced osteonecrosis of the femoral head

被引：30

作者：

Du, Jieli ^{[1
,2
]}

Liu, Wanlin ^{[2
]}

Jin, Tianbo ^{[3
]}

Zhao, Zhenqun ^{[2
]}

Bai, Rui ^{[2
]}

Xue, Huiqin ^{[2
]}

Chen, Junyu ^{[1
,2
]}

Sun, Mingqi ^{[2
]}

Zhang, Xiyang ^{[3
]}

Wang, Guoqiang ^{[2
]}

Wang, Jianzhong ^{[2
]}

机构：

[1] Inner Mongolia Med Univ, Hohhot 010050, Inner Mongolia, Peoples R China

[2] Inner Mongolia Univ, Dept Orthoped & Traumatol, Affiliated Hosp 2, Hohhot 010030, Inner Mongolia, Peoples R China

[3] Northwest Univ, Coll Life Sci, Xian 710069, Peoples R China

来源：

ONCOTARGET | 2016年 / 7卷 / 42期

基金：

中国国家自然科学基金;

关键词：

MMP9; MMP2; single nucleotide polymorphisms; osteonecrosis of the femoral head; association study; CHINESE HAN POPULATION; MATRIX METALLOPROTEINASES; GENE POLYMORPHISM; TISSUE INHIBITORS; EXPRESSION; MATRIX-METALLOPROTEINASE-9; BONE; ARTHRITIS; SUSCEPTIBILITY; CHONDROCYTES;

D O I：

10.18632/oncotarget.12034

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Osteonecrosis of the femoral head (ONFH) is a common hip joint disease, and steroid-induced ONFH accounts for a large number of cases. Here, we examined eight previously-identified single-nucleotide polymorphisms (SNPs) in the MPP2 and MPP9 genes of 285 steroid-induced ONFH patients and 507 healthy controls from northern China to determine whether these SNPs were associated with the risk of developing steroid-induced ONFH. Chi-squared tests and genetic model and haplotype analyses were used to evaluate associations. The rs2274755 SNP in MMP9 was associated with a decreased risk of steroid-induced ONFH in the allele, dominant, and additive models. Additionally, the "CGC" MMP9 haplotype was associated with a 0.69-fold decrease in the risk of steroid-induced ONFH. Although additional, larger population-based studies are needed to confirm these findings, our results reveal for the first time an association between a MMP9 SNP at the rs2274755 locus and a decreased risk of steroid-induced ONFH in a northern Chinese population.

引用

页码：68434 / 68441

页数：8

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