PREVALENCE OF ATOPIC SYMPTOMS AMONG BLOOD DONOR CARRIERS OF MANNOSE-BINDING LECTIN VARIANT ALLELES

被引：6

作者：

Cardinale, F. ^{[1
]}

Chinellato, I. ^{[1
]}

Marseglia, G. L. ^{[2
]}

Nettis, E. ^{[3
]}

Polizzi, A. ^{[1
]}

Loffredo, M. S. ^{[1
]}

Santostasi, T. ^{[1
]}

Tesse, R. ^{[1
]}

Trerotoli, P. ^{[4
]}

Di Monte, D. ^{[5
]}

Armenio, L. ^{[1
]}

机构：

[1] Univ Bari, Dept Pediat, Sch Med, I-70124 Bari, Italy

[2] Univ Pavia, Dept Pediat, Sch Med, I-27100 Pavia, Italy

[3] Univ Bari, Dept Allergy & Clin Immunol, Sch Med, I-70124 Bari, Italy

[4] Univ Bari, Dept Internal & Publ Med, Sch Med, I-70124 Bari, Italy

[5] Azienda Osped Policlin, Dept Internal Med, Transfus Unit, Bari, Italy

来源：

INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY | 2008年 / 21卷 / 03期

关键词：

D O I：

10.1177/039463200802100329

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Mannose-binding lectin (MBL) is a C-type soluble collectin involved in the innate immune response. Carriers of MBL gene variant alleles (MBLva) have decreased plasma concentrations of MBL and increased susceptibility to bacterial and viral infections. The aim of the present study is to test the hypothesis that carriers of MBLva could have a different frequency of atopic symptoms as compared to wild-type carriers. A total of 385 consecutively enrolled Caucasian blood donors were studied. Blood specimens underwent genomic analysis and genotyping for MBLva by polymerase chain reaction (PCR). MBLva carrier status was associated with a reduced frequency of allergic rhinitis (OR 0.41 [95% Cl 0.2 to 0.8], chi(2) = 6.98, p=.008). No relationship was found between MBLva carrier status and asthma or atopic skin symptoms. MBLva might be one of the host-related genetic factors involved in atopic disorders, namely allergic rhinitis.

引用

页码：735 / 738

页数：4

共 11 条

[1]

Mannose-binding lectin (MBL) deficiency. Variant alleles in a Midwestern population of the United States [J].