11β-Hydroxylase and aldosterone synthase expression in fetal rat hippocampal neurons

被引：19

作者：

MacKenzie, S. M. ^{[1
]}

Lai, M. ^{[2
]}

Clark, C. J. ^{[3
]}

Fraser, R. ^{[1
]}

Gomez-Sanchez, C. E. ^{[4
,5
]}

Seckl, J. R. ^{[2
]}

Connell, J. M. C. ^{[1
]}

Davies, E. ^{[1
]}

机构：

[1] Univ Glasgow, Western Infirm, Dept Med & Therapeut, Blood Pressure Grp, Glasgow G11 6NT, Lanark, Scotland

[2] Western Gen Hosp, Mol Med Ctr, Endocrinol Unit, Mol Endocrinol Lab, Edinburgh EH4 2XU, Midlothian, Scotland

[3] Univ Glasgow, Inst Biomed & Life Sci, Glasgow G12 8QQ, Lanark, Scotland

[4] GV Montgomery VA Hosp, Endocrinol, Columbia, MO 65201 USA

[5] Univ Mississippi, Jackson, MS USA

来源：

JOURNAL OF MOLECULAR ENDOCRINOLOGY | 2002年 / 29卷 / 03期

基金：

英国惠康基金;

关键词：

D O I：

10.1677/jme.0.0290319

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

The central nervous system produces many of the enzymes responsible for corticosteroid synthesis. A model system to study the regulation of this local system would be valuable. Previously, we have shown that primary cultures of hippocampal neurons isolated from the fetal rat can perform the biochemical reactions associated with the enzymes 11 beta-hydroxylase and aldosterone synthase. Here, we demonstrate directly that these enzymes are present within primary cultures of fetal rat hippocampal neurons.

引用

页码：319 / 325

页数：7

共 24 条

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IMMUNOCHEMICAL DETECTION OF THE MINERALOCORTICOID RECEPTOR IN RAT-BRAIN [J].