The molecular mechanism of mitochondrial fusion

被引：108

作者：

Hoppins, Suzanne ^{[1
]}

Nunnari, Jodi ^{[1
]}

机构：

[1] Univ Calif Davis, Dept Mol & Cellular Biol, Davis, CA 95616 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2009年 / 1793卷 / 01期

关键词：

Membrane dynamic; Mitochondrial fusion; Dynamin; DYNAMIN-RELATED GTPASE; INTERMEMBRANE SPACE PROTEIN; CYTOCHROME-C RELEASE; ALTERNATIVE TOPOGENESIS; CRYSTAL-STRUCTURE; DOMAIN; OPA1; MAINTENANCE; MORPHOLOGY; MGM1P;

D O I：

10.1016/j.bbamcr.2008.07.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This review is focused on mitochondrial membrane fusion, which is a highly conserved process from yeast to human cells. We present observations from both yeast and mammalian cells that have provided insights into the mechanism of mitochondrial fusion and speculate on how the key players, which are dynamin-related GTPases do the work of membrane tethering and fusion. (C) 2008 Published by Elsevier B.V.

引用

页码：20 / 26

页数：7

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