Determination of trace elements in human brain tissues using neutron activation analysis

被引：15

作者：

Leite, R. E. P. ^{[1
]}

Jacob-Filho, W. ^{[1
]}

Saiki, M. ^{[2
]}

Grinberg, L. T. ^{[1
]}

Ferretti, R. E. L. ^{[1
]}

机构：

[1] Univ Sao Paulo, Fac Med, BR-05403010 Sao Paulo, Brazil

[2] IPEN CNEN SP, BR-05508000 Sao Paulo, Brazil

来源：

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY | 2008年 / 278卷 / 03期

基金：

巴西圣保罗研究基金会;

关键词：

D O I：

10.1007/s10967-008-1009-8

中图分类号：

O65 [分析化学];

学科分类号：

070302 [分析化学]; 081704 [应用化学];

摘要：

Neutron activation analysis was applied to assess trace element concentrations in brain tissues from normal (n = 21) and demented individuals (n = 21) of both genders aged more than 50 years. Concentrations of the elements Br, Fe, K, Na, Rb, Se and Zn were determined. Comparisons were made between the results obtained for the hippocampus and frontal cortex tissues, as well as, those obtained in brains of normal and demented individuals. Certified reference materials, NIST 1566b Oyster Tissue and NIST 1577b Bovine Liver were analyzed for quality of the analytical results.

引用

页码：581 / 584

页数：4

共 17 条

[1]

Brain regional distributions of the minor and trace elements, Na, Mg, Cl, K, Mn, Zn, Rb and Br, in young and aged mice [J].

Amano, R ;

Oishi, S ;

Ishie, M ;

Kimura, M .

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY, 2001, 247 (02) :381-384

[2]

Changes in the ageing brain in health and disease [J].

Anderton, BH .

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES, 1997, 352 (1363) :1781-1792

[3]

AL, ZN, CU, MN AND FE LEVELS IN BRAIN IN ALZHEIMERS-DISEASE [J].

ANDRASI, E ;

FARKAS, E ;

SCHEIBLER, H ;

REFFY, A ;

BEZUR, L .

ARCHIVES OF GERONTOLOGY AND GERIATRICS, 1995, 21 (01) :89-97

[4]

Several methods to determine heavy metals in the human brain [J].

Andrási, E ;

Igaz, S ;

Szoboszlai, N ;

Farkas, E ;

Ajtony, Z .

SPECTROCHIMICA ACTA PART B-ATOMIC SPECTROSCOPY, 1999, 54 (05) :819-825

[5]

Determination of alkali metals in control and AD brain samples by different techniques [J].

Bélavária, C ;

Andrási, E ;

Molnár, Z ;

Bertalan, É .

MICROCHEMICAL JOURNAL, 2005, 79 (1-2) :367-373

[6]

Bode P, 1996, THESIS DELFT U TECHN, P148

[7]

The metallobiology of Alzheimer's disease [J].

Bush, AI .

TRENDS IN NEUROSCIENCES, 2003, 26 (04) :207-214

[8]

Copper, iron, and zinc imbalances in severely degenerated brain regions in Alzheimer's disease: Possible relation to oxidative stress [J].

Deibel, MA ;

Ehmann, WD ;

Markesbery, WR .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 1996, 143 (1-2) :137-142

[9]

Brain bank of the Brazilian aging brain study group - A milestone reached and more than 1,600 collected brains [J].

Grinberg L.T. ;

Lucena Ferretti R.E. ;

Farfel J.M. ;

Leite R. ;

Pasqualucci C.A. ;

Rosemberg S. ;

Nitrini R. ;

Saldiva P.H.N. ;

Jacob Filho W. .

Cell and Tissue Banking, 2007, 8 (2) :151-162

[10]

Brain trace elements and aging [J].

Hebbrecht, G ;

Maenhaut, W ;

De Reuck, J .

NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS, 1999, 150 (1-4) :208-213

← 1 2 →