3-alkyl-(5,5′-diphenyl)imidazolidinediones as new cannabinoid receptor ligands

被引：24

作者：

Kanyonyo, M

Govaerts, SJ

Hermans, E

Poupaert, JH

Lambert, DM

机构：

[1] Catholic Univ Louvain, Unite Chim Pharmaceut & Radiopharm, B-1200 Brussels, Belgium

[2] Catholic Univ Louvain, Unite Chim Pharmaceut & Radiopharm, B-1200 Brussels, Belgium

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 15期

关键词：

D O I：

10.1016/S0960-894X(99)00353-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Twenty-four 3-alkyl-(5,5'-diphenyl)imidazolidinediones were synthesized and evaluated as new cannabinoid receptor ligands. Three compounds exhibited a Ki value around 100 nM against [H-3]-SR 141716A binding obtained from human CB1 transfected CHO cells membranes. The lack of change of affinity in the presence of a non hydrolyzable GTP analogue seems to indicate they are cannabinoid antagonists. (C) 1999 Elsevier Science Ltd. All rights reserved.

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页码：2233 / 2236

页数：4

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