Rho-GTPase and Atherosclerosis: Pleiotropic Effects of Statins

被引：51

作者：

Cai, Anping ^{[1
]}

Zhou, Yingling ^{[1
]}

Li, Liwen ^{[1
]}

机构：

[1] Guangdong Acad Med Sci, Guangdong Cardiovasc Inst, Guangdong Gen Hosp, Dept Cardiol, Guangzhou 510080, Guangdong, Peoples R China

来源：

JOURNAL OF THE AMERICAN HEART ASSOCIATION | 2015年 / 4卷 / 07期

关键词：

atherosclerotic cardiovascular diseases; Rho-GTPase; statins; NITRIC-OXIDE SYNTHASE; HMG-COA REDUCTASE; HUMAN ENDOTHELIAL-CELLS; CORONARY-HEART-DISEASE; SMOOTH-MUSCLE-CELLS; ACUTE MYOCARDIAL-INFARCTION; INDUCED DOWN-REGULATION; PROTEIN-KINASE; CARDIAC-HYPERTROPHY; THERAPEUTIC TARGET;

D O I：

10.1161/JAHA.115.002113

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

[No abstract available]

引用

收藏

页数：9

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共 95 条

[1]

MEVINOLIN - A HIGHLY POTENT COMPETITIVE INHIBITOR OF HYDROXYMETHYLGLUTARYL-COENZYME-A REDUCTASE AND A CHOLESTEROL-LOWERING AGENT [J].

ALBERTS, AW ;

CHEN, J ;

KURON, G ;

HUNT, V ;

HUFF, J ;

HOFFMAN, C ;

ROTHROCK, J ;

LOPEZ, M ;

JOSHUA, H ;

HARRIS, E ;

PATCHETT, A ;

MONAGHAN, R ;

CURRIE, S ;

STAPLEY, E ;

ALBERSSCHONBERG, G ;

HENSENS, O ;

HIRSHFIELD, J ;

HOOGSTEEN, K ;

LIESCH, J ;

SPRINGER, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (07) :3957-3961

[2]

A role for Cdc42 in macrophage chemotaxis [J].

Allen, WE ;

Zicha, D ;

Ridley, AJ ;

Jones, GE .

JOURNAL OF CELL BIOLOGY, 1998, 141 (05) :1147-1157

[3]

Regulation of macrophage cholesterol efflux through hydroxymethylglutaryl-CoA reductase inhibition [J].

Argmann, CA ;

Edwards, JY ;

Sawyez, CG ;

O'Neil, CH ;

Hegele, RA ;

Pickering, JG ;

Huff, MW .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (23) :22212-22221

[4]

Rho GTPases in platelet function [J].

Aslan, J. E. ;

Mccarty, O. J. T. .

JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2013, 11 (01) :35-46

[5]

p21 Activated Kinase Signaling Coordinates Glycoprotein Receptor VI-Mediated Platelet Aggregation, Lamellipodia Formation, and Aggregate Stability Under Shear [J].

Aslan, Joseph E. ;

Itakura, Asako ;

Haley, Kristina M. ;

Tormoen, Garth W. ;

Loren, Cassandra P. ;

Baker, Sandra M. ;

Pang, Jiaqing ;

Chernoff, Jonathan ;

McCarty, Owen J. T. .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2013, 33 (07) :1544-1551

[6]

Involvement of geranylgeranylation of Rho and Rac GTPases in adipogenic and RANKL expression, which was inhibited by simvastatin [J].

Baba, T. T. ;

Ohara-Nemoto, Y. ;

Miyazaki, T. ;

Nemoto, T. K. .

CELL BIOCHEMISTRY AND FUNCTION, 2013, 31 (08) :652-659

[7]

Atorvastatin inhibits homocysteine-induced dysfunction and apoptosis in endothelial progenitor cells [J].

Bao, Xiao-mei ;

Wu, Chun-fang ;

Lu, Guo-ping .

ACTA PHARMACOLOGICA SINICA, 2010, 31 (04) :476-484

[8]

BIOSYNTHESIS AND CHARACTERIZATION OF (S) AND (R)-3-HYDROXY-3-METHYLGLUTARYL COENZYME-A [J].

BISCHOFF, KM ;

RODWELL, VW .

BIOCHEMICAL MEDICINE AND METABOLIC BIOLOGY, 1992, 48 (02) :149-158

[9]

Statin treatment and new-onset diabetes: A review of proposed mechanisms [J].

Brault, Marilyne ;

Ray, Jessica ;

Gomez, Yessica-Haydee ;

Mantzoros, Christos S. ;

Daskalopoulou, Stella S. .

METABOLISM-CLINICAL AND EXPERIMENTAL, 2014, 63 (06) :735-745

[10]

Cell cycle progression - New therapeutic target for vascular proliferative disease [J].

Braun-Dullaeus, RC ;

Mann, MJ ;

Dzau, VJ .

CIRCULATION, 1998, 98 (01) :82-89

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