Time To Move from Presumptive Malaria Treatment to Laboratory-Confirmed Diagnosis and Treatment in African Children with Fever

被引：156

作者：

D'Acremont, Valerie ^{[1
,3
]}

Lengeler, Christian ^{[1
]}

Mshinda, Hassan ^{[2
]}

Mtasiwa, Deo ^{[4
]}

Tanner, Marcel ^{[1
]}

Genton, Blaise ^{[1
,2
]}

机构：

[1] Swiss Trop Inst, CH-4002 Basel, Switzerland

[2] Ifakara Hlth Inst, Dar Es Salaam, Tanzania

[3] Dar Es Salaam City Council, City Med Off Hlth, Dar Es Salaam, Tanzania

[4] Minist Hlth & Social Welf, Dar Es Salaam, Tanzania

来源：

PLOS MEDICINE | 2009年 / 6卷 / 01期

关键词：

COMBINATION THERAPY; COST-EFFECTIVENESS; FEBRILE ILLNESS; TANZANIA; TESTS; TRANSMISSION; INTENSITY; ERA;

D O I：

10.1371/journal.pmed.0050252

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background to the debate: Current guidelines recommend that all fever episodes in African children be treated presumptively with antimalarial drugs. But declining malarial transmission in parts of sub-Saharan Africa, declining proportions of fevers due to malaria, and the availability of rapid diagnostic tests mean it may be time for this policy to change. This debate examines whether enough evidence exists to support abandoning presumptive treatment and whether African health systems have the capacity to support a shift toward laboratory-confirmed rather than presumptive diagnosis and treatment of malaria in children under five.

引用

页码：4 / 6

页数：3

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