Induction of myelin gene expression in Schwann cell cultures by an interleukin-6 receptor-interleukin-6 chimera

被引：22

作者：

Haggiag, S ^{[1
]}

Chebath, J ^{[1
]}

Revel, M ^{[1
]}

机构：

[1] Weizmann Inst Sci, Dept Mol Genet, IL-76100 Rehovot, Israel

来源：

FEBS LETTERS | 1999年 / 457卷 / 02期

关键词：

myelination; Po protein; myelin basic protein; Schwann cell; interleukin-6; receptor;

D O I：

10.1016/S0014-5793(99)01040-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Expression of myelin basic protein (NLBP) and Po gene products is induced during the final postnatal maturation of Schwann cells and reinduced during nerve regeneration. We show that a chimeric protein containing interleukin-6 fused to its soluble receptor (IL6RIL6 chimera) induces MBP and Po RNAs and proteins in cultures of dorsal root ganglia (DRG) from 14 day old mouse embryos. Activation of gp130 signaling by IL6RIL6 appears comparable to cyclic AMP elevating agents to induce: the myelin gene products in DRG and in pure Schwann cell cultures. (C) 1999 Federation of European Biochemical Societies.

引用

页码：200 / 204

页数：5

共 48 条

[1]

BOLIN LM, 1995, J NEUROCHEM, V64, P850

[2] Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway [J].

Bonni, A ;

Sun, Y ;

NadalVicens, M ;

Bhatt, A ;

Frank, DA ;

Rozovsky, I ;

Stahl, N ;

Yancopoulos, GD ;

Greenberg, ME .

SCIENCE, 1997, 278 (5337) :477-483

[3] MOVEMENTS OF THE SCHWANN-CELL NUCLEUS IMPLICATE PROGRESSION OF THE INNER (AXON-RELATED) SCHWANN-CELL PROCESS DURING MYELINATION [J].

BUNGE, RP ;

BUNGE, MB ;

BATES, M .

JOURNAL OF CELL BIOLOGY, 1989, 109 (01) :273-284

[4]

CAMPAGNONI AT, 1993, J BIOL CHEM, V268, P4930

[5] The neuregulin, glial growth factor 2, diminishes autoimmune demyelination and enhances remyelination in a chronic relapsing model for multiple sclerosis [J].

Cannella, B ;

Hoban, CJ ;

Gao, YL ;

Garcia-Arenas, R ;

Lawson, D ;

Marchionni, M ;

Gwynne, D ;

Raine, CS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (17) :10100-10105

[6]

Chebath J, 1997, EUR CYTOKINE NETW, V8, P359

[7] Recombinant human glial growth factor 2 (rhGGF 2) improves functional recovery of crushed peripheral nerve (a double-blind study) [J].

Chen, LE ;

Liu, K ;

Seaber, AV ;

Katragadda, S ;

Kirk, C ;

Urbaniak, JR .

NEUROCHEMISTRY INTERNATIONAL, 1998, 33 (04) :341-351

[8] Cultured schwann cells constitutively express the myelin protein P-0 [J].

Cheng, LL ;

Mudge, AW .

NEURON, 1996, 16 (02) :309-319

[9] Involvement of MAP kinase in the cyclic AMP induction of myelin basic protein gene expression [J].

Clark, R ;

Stewart, M ;

Miskimins, WK ;

Miskimins, R .

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, 1998, 16 (05) :323-331

[10] SERUM-SOLUBLE INTERLEUKIN-6 (IL-6) RECEPTOR AND IL-6 SOLUBLE IL-6 RECEPTOR COMPLEX IN SYSTEMIC JUVENILE RHEUMATOID-ARTHRITIS [J].

DEBENEDETTI, F ;

MASSA, M ;

PIGNATTI, P ;

ALBANI, S ;

NOVICK, D ;

MARTINI, A .

JOURNAL OF CLINICAL INVESTIGATION, 1994, 93 (05) :2114-2119

← 1 2 3 4 5 →