Does Reduced Creatine Synthesis Protect against Statin Myopathy?

被引：15

作者：

Ballard, Kevin D. ^{[1
]}

Thompson, Paul D. ^{[1
]}

机构：

[1] Hartford Hosp, Henry Low Heart Ctr, Div Cardiol, Hartford, CT 06102 USA

来源：

CELL METABOLISM | 2013年 / 18卷 / 06期

关键词：

D O I：

10.1016/j.cmet.2013.11.012

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Statins, widely used to lower cholesterol levels, cause myopathy in some patients. Mangravite et al. (2013) show that a single nucleotide polymorphism decreasing expression of glycine amidinotransferase (GATM), the enzyme regulating creatine biosynthesis, is associated with reduced statin myopathy. Whether reduced creatine production protects against statin myopathy remains to be determined.

引用

页码：773 / 774

页数：2

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