The MIntAct project-IntAct as a common curation platform for 11 molecular interaction databases

被引：1249

作者：

Orchard, Sandra ^{[1
]}

Ammari, Mais ^{[2
]}

Aranda, Bruno ^{[1
]}

Breuza, Lionel ^{[3
]}

Briganti, Leonardo ^{[4
]}

Broackes-Carter, Fiona ^{[5
,6
]}

Campbell, Nancy H. ^{[7
]}

Chavali, Gayatri ^{[1
]}

Chen, Carol ^{[8
]}

del-Toro, Noemi ^{[1
]}

Duesbury, Margaret ^{[1
]}

Dumousseau, Marine ^{[1
]}

Galeota, Eugenia ^{[4
]}

Hinz, Ursula ^{[3
]}

Iannuccelli, Marta

Jagannathan, Sruthi ^{[9
]}

Jimenez, Rafael ^{[1
]}

Khadake, Jyoti ^{[1
]}

Lagreid, Astrid ^{[10
]}

Licata, Luana ^{[4
]}

Lovering, Ruth C. ^{[7
]}

Meldal, Birgit ^{[1
]}

Melidoni, Anna N. ^{[7
]}

Milagros, Mila ^{[1
]}

Peluso, Daniele ^{[11
]}

Perfetto, Livia ^{[4
]}

Porras, Pablo ^{[1
]}

Raghunath, Arathi ^{[12
]}

Ricard-Blum, Sylvie ^{[13
]}

Roechert, Bernd ^{[3
]}

Stutz, Andre ^{[3
]}

Tognolli, Michael ^{[3
]}

van Roey, Kim ^{[14
]}

Cesareni, Gianni ^{[4
,11
]}

Hermjakob, Henning ^{[1
]}

机构：

[1] European Bioinformat Inst EMBL EBI, European Mol Biol Lab, Cambridge CB10 1SD, England

[2] Univ Arizona, Sch Anim & Comparat Biomed Sci, Tucson, AZ 85721 USA

[3] CMU, SIB Swiss Inst Bioinformat, Swiss Prot Grp, CH-1211 Geneva 4, Switzerland

[4] Univ Roma Tor Vergata, Dept Biol, I-00133 Rome, Italy

[5] Univ Hlth Network, Ontario Canc Inst, Campbell Family Inst Canc Res, Toronto, ON M5G 0A3, Canada

[6] Univ Hlth Network, Techna Inst, Toronto, ON M5G 0A3, Canada

[7] UCL, Inst Cardiovasc Sci, Ctr Cardiovasc Genet, Cardiovasc Gene Annotat Initiat, London WC1E 6BT, England

[8] Univ British Columbia, Ctr Microbial Dis & Immun Res, Vancouver, BC V6T 1Z4, Canada

[9] Natl Univ Singapore, Inst Mechanobiol, Singapore 117411, Singapore

[10] Norwegian Univ Sci & Technol, Dept Canc Res & Mol Med, N-7489 Trondheim, Norway

[11] IRCSS Fdn Santa Lucia, Res Inst, I-00179 Rome, Italy

[12] Mol Connect Pvt Ltd, Bangalore 560004, Karnataka, India

[13] Univ Lyon 1, CNRS, Inst Biol & Chim Prot, Unite Mixte Rech 5086, F-69365 Lyon, France

[14] European Mol Biol Lab, Struct & Computat Biol Unit, D-69117 Heidelberg, Germany

来源：

NUCLEIC ACIDS RESEARCH | 2014年 / 42卷 / D1期

关键词：

RESOURCE; WEB;

D O I：

10.1093/nar/gkt1115

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

IntAct (freely available at http://www.ebi.ac.uk/intact) is an open-source, open data molecular interaction database populated by data either curated from the literature or from direct data depositions. IntAct has developed a sophisticated web-based curation tool, capable of supporting both IMEx- and MIMIx-level curation. This tool is now utilized by multiple additional curation teams, all of whom annotate data directly into the IntAct database. Members of the IntAct team supply appropriate levels of training, perform quality control on entries and take responsibility for long-term data maintenance. Recently, the MINT and IntAct databases decided to merge their separate efforts to make optimal use of limited developer resources and maximize the curation output. All data manually curated by the MINT curators have been moved into the IntAct database at EMBL-EBI and are merged with the existing IntAct dataset. Both IntAct and MINT are active contributors to the IMEx consortium (http://www.imexconsortium.org).

引用

页码：D358 / D363

页数：6

共 27 条

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