Innate type 2 cells and asthma

Asthma and other allergic conditions are immunologically described as Th2 skewed, with associated increases in IgE, eosinophila and expression of IL-4, IL-5 and IL-13. However, recent advances have implicated other type 2 cytokines such as IL-25, IL-33 and TSLP in the pathogenesis of allergic conditions. These cytokines are potent inducers of the panel of recently described innate immune cells, which also produce large amounts of the Th2 cytokines IL-5 and IL-13 independent of the adaptive immune response. We review herein, the role for these innate cell populations with a focus on the nuocyte, in allergic asthma and pulmonary inflammation.