Fornix, medial prefrontal cortex, nucleus accumbens, and mediodorsal thalamic nucleus: Roles in a fear-based context discrimination task

被引:49
作者
Antoniadis, EA
McDonald, RJ
机构
[1] Univ Calif Davis, Calif Natl Primate Res Ctr, Davis, CA 95616 USA
[2] Univ Calif Davis, Dept Psychiat & Behav Sci, Davis, CA 95616 USA
[3] Univ Lethbridge, Canadian Ctr Behav Neurosci, Lethbridge, AB T1K 3M4, Canada
[4] Univ Lethbridge, Dept Psychol & Neurosci, Lethbridge, AB T1K 3M4, Canada
关键词
amygdala; hippocampus; context fear conditioning;
D O I
10.1016/j.nlm.2005.08.011
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 [法学]; 0303 [社会学]; 030303 [人类学]; 04 [教育学]; 0402 [心理学];
摘要
The goal of the present study was to evaluate the contributions of various brain structures anatomically and functionally linked to the hippocampus and amygdala in a fear-based context discrimination task. The brain areas of interest included the fornix, medial prefrontal cortex, mediodorsal (MD) thalamic nucleus, and nucleus accumbens. Damage to the MD thalamic nucleus and medial prefrontal cortex produced the largest impairment in context-specific fear responses. Damage to the fornix impaired some fear responses (freezing, ultrasonic vocalizations, defecation, and approach/avoidance) while leaving conditioned fear expression of heart rate and urination unaltered. Damage to the nucleus accumbens was also coupled with deficits in the discriminative expression of some (heart rate, urination, and ultrasonic vocalizations) but sparing of context-appropriate freezing, defecation, and approach/avoidance behaviors. (c) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码:71 / 85
页数:15
相关论文
共 50 条
[1]
AMARAL DG, 1987, HDB PHYSL, V5
[2]
SEPTO-HIPPOCAMPAL PATHWAY NECESSARY FOR DENTATE THETA PRODUCTION [J].
ANDERSEN, P ;
BLAND, HB ;
MYHRER, T ;
SCHWARTZKROIN, PA .
BRAIN RESEARCH, 1979, 165 (01) :13-22
[3]
[Anonymous], 1985, CONTEXT LEARNING, DOI DOI 10.4324/9781315802466
[4]
[Anonymous], AMYGDALA NEUROBIOLOG
[5]
Circadian rhythms, aging and memory [J].
Antoniadis, EA ;
Ko, CH ;
Ralph, MR ;
McDonald, RJ .
BEHAVIOURAL BRAIN RESEARCH, 2000, 111 (1-2) :25-37
[6]
MAUDSLEY REACTIVE AND NONREACTIVE STRAINS OF RATS - SURVEY [J].
BROADHURST, PL .
BEHAVIOR GENETICS, 1975, 5 (04) :299-319
[7]
DIVAC I, 1994, PROG BRAIN RES, V100, P169
[8]
Lesions of the entorhinal cortex disrupt behavioral and neuronal responses to context change during extinction of discriminative avoidance behavior [J].
Freeman, JH ;
Weible, A ;
Rossi, J ;
Gabriel, M .
EXPERIMENTAL BRAIN RESEARCH, 1997, 115 (03) :445-457
[9]
Gabriel M., 1993, Neurobiology of Cingulate Cortex and Limbic Thalamus: A Comprehensive Handbook, P478, DOI [10.1007/978-1-4899-6704-6_18, DOI 10.1007/978-1-4899-6704-6_18]
[10]