Formation of filamentous tau aggregations in transgenic mice expressing V337M human tau

被引：111

作者：

Tanemura, K

Akagi, T

Murayama, M

Kikuchi, N

Murayama, O

Hashikawa, T

Yoshiike, Y

Park, JM

Matsuda, K

Nakao, S

Sun, XY

Sato, S

Yamaguchi, H

Takashima, A

机构：

[1] RIKEN, Brain Sci Inst, Lab Alzheimers Dis, Wako, Saitama 3510198, Japan

[2] Gunma Univ, Sch Hlth Sci, Gunma, Japan

[3] Tokyo Inst Technol, Dept Life Sci, Yokohama, Kanagawa 227, Japan

来源：

NEUROBIOLOGY OF DISEASE | 2001年 / 8卷 / 06期

基金：

日本科学技术振兴机构;

关键词：

D O I：

10.1006/nbdi.2001.0439

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Formation of neurofibrillary tangles (NFTs) is the most common feature in several neurodegenerative diseases, including Alzheimer's disease (AD). Here we report the formation of filamentous tau aggregations having a beta -sheet structure in transgenic mice expressing mutant human tau. These mice contain a tau gene with a mutation of the frontotemporal dementia parkinsonism (FTDP-17) type, in which valine is substituted with methionine residue 337. The aggregation of tau in these transgenic mice satisfies all histological criteria used to identify NFTs common to human neurodegenerative diseases. These mice, therefore, provide a preclinical model for the testing of therapeutic drugs for the treatment of neurodegenerative disorders that exhibit NFTs. (C) 2001 Elsevier Science.

引用

页码：1036 / 1045

页数：10

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