Pharmacological profile of new deamino analogues of sabarubicin (MEN 10755)

被引：3

作者：

Bigioni, M ^{[1
]}

Salvatore, C ^{[1
]}

Cipollone, A ^{[1
]}

Berettoni, M ^{[1
]}

Maggi, CA ^{[1
]}

Binaschi, M ^{[1
]}

机构：

[1] Menarini Ric SpA, Dept Pharmacol, I-00040 Monte Porzio Catone, Italy

来源：

LETTERS IN DRUG DESIGN & DISCOVERY | 2005年 / 2卷 / 01期

关键词：

sabarubicin; MEN; 10755; 10959; 12297; anthracycline disaccharides; DNA topoisomerase;

D O I：

10.2174/1570180053398307

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Sabarubicin (MEN 10755) is the progenitor of a third generation of synthetic anthracycline oligosaccharides. Sabarubicin deamino analogues MEN 10959 and MEN 12297 were evaluated for topoisomerase II poisoning, cytotoxic potency and antitumor activity in human xenografts. The new analogues were able to induce DNA cleavage mediated by both DNA topoisomerase II alpha and beta and a good correlation was found regarding their cytotoxic activity. The two analogues possess also a different spectrum of antitumor activity, compared to sabarubicin.

引用

页码：68 / 73

页数：6

共 25 条

[1] Doxorubicin disaccharide analogue: Apoptosis-related improvement of efficacy in vivo
Arcamone, F
Animati, F
Berettoni, M
Bigioni, M
Capranico, G
Casazza, AM
Caserini, C
Cipollone, A
DeCesare, M
Franciotti, M
Lombardi, P
Madami, A
Manzini, S
Monteagudo, E
Polizzi, D
Pratesi, G
Righetti, SC
Salvatore, C
Supino, R
Zunino, F
[J]. JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1997, 89 (16) : 1217 - 1223
[2] Configurational requirements of the sugar moiety for the pharmacological activity of anthracycline disaccharides
Arcamone, F
Animati, F
Bigioni, M
Capranico, G
Caserini, C
Cipollone, A
De Cesare, M
Ettorre, A
Guano, F
Manzini, S
Monteagudo, E
Pratesi, G
Salvatore, C
Supino, R
Zunino, F
[J]. BIOCHEMICAL PHARMACOLOGY, 1999, 57 (10) : 1133 - 1139
[3] Arcamone F., 1981, DOXORUBICIN ANTICANC
[4] BEVERLY AT, 1997, ANTICANCER DRUG DEV
[5] Brown JM, 1999, CANCER RES, V59, P1391
[6] Mechanism of action of eukaryotic topoisomerase II and drugs targeted to the enzyme
Burden, DA
Osheroff, N
[J]. BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1998, 1400 (1-3): : 139 - 154
[7] CAPRANICO G, 1994, MOL PHARMACOL, V45, P908
[8] CAPRANICO G, 1995, CANCER RES, V55, P312
[9] Novel anthracycline oligosaccharides: Influence of chemical modifications of the carbohydrate moiety on biological activity
Cipollone, A
Berettoni, M
Bigioni, M
Binaschi, M
Cermele, C
Monteagudo, E
Olivieri, L
Palomba, D
Animati, F
Goso, C
Maggi, CA
[J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2002, 10 (05) : 1459 - 1470
[10] THE PARA-METHOXYBENZYL GROUP AS PROTECTIVE GROUP OF THE ANOMERIC CENTER - SELECTIVE CONVERSIONS OF HYDROXY-GROUPS INTO BROMO GROUPS IN PARA-METHOXYBENZYL 2-DEOXY-2-PHTHALIMIDO-BETA-D-GLUCOPYRANOSIDE
CLASSON, B
GAREGG, PJ
SAMUELSSON, B
[J]. ACTA CHEMICA SCANDINAVICA SERIES B-ORGANIC CHEMISTRY AND BIOCHEMISTRY, 1984, 38 (05): : 419 - 422

← 1 2 3 →